Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles

Abstract The potential effects of high basal luteinizing hormone (LH) levels on human reproduction were controversial. To demonstrate the effects of elevated basal LH levels on the outcome of patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles, we performed...

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Autores principales:	Lihua Sun, Jing Ye, Yun Wang, Qiuju Chen, Renfei Cai, Yonglun Fu, Hui Tian, Qifeng Lyu, Xuefeng Lu, Yanping Kuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	In Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI) PCOS Patients Polycystic Ovary Syndrome (PCOS) Oocyte Retrieval High Basal LH Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4539208a737143fc81e86fdfcaafe539
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spelling	oai:doaj.org-article:4539208a737143fc81e86fdfcaafe5392021-12-02T15:08:57ZElevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles10.1038/s41598-018-32128-42045-2322https://doaj.org/article/4539208a737143fc81e86fdfcaafe5392018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32128-4https://doaj.org/toc/2045-2322Abstract The potential effects of high basal luteinizing hormone (LH) levels on human reproduction were controversial. To demonstrate the effects of elevated basal LH levels on the outcome of patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles, we performed a retrospective data analysis of 1011 polycystic ovarian syndrome (PCOS) patients treated with human menopausal gonadotropin and medroxyprogesterone acetate (hMG + MPA) protocol at our center between Nov. 2013 and Jun. 2017. PCOS patients with elevated basal LH levels had significantly higher LH exposure during the stimulation period. The group with LH ≥ 10 mIU/mL showed a lower mean total hMG dose used but higher numbers of oocytes retrieved, metaphase II oocytes, embryos and top-quality embryos developed than the groups with lower basal LH levels. Moreover, partial correlation analysis showed that the basal LH level was negatively correlated with the total hMG dose but positively correlated with the numbers of oocytes retrieved, metaphase II oocytes, embryos, and top-quality embryos. There were no significant differences in the rates of oocyte retrieval, fertilization, implantation, clinical pregnancy and miscarriage between the groups based on frozen embryo transfer (FET). We concluded that elevated basal LH level does not impair the final outcome of hMG + MPA-treated IVF/ICSI cycles in PCOS women.Lihua SunJing YeYun WangQiuju ChenRenfei CaiYonglun FuHui TianQifeng LyuXuefeng LuYanping KuangNature PortfolioarticleIn Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI)PCOS PatientsPolycystic Ovary Syndrome (PCOS)Oocyte RetrievalHigh Basal LHMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	In Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI) PCOS Patients Polycystic Ovary Syndrome (PCOS) Oocyte Retrieval High Basal LH Medicine R Science Q
spellingShingle	In Vitro Fertilization/intracytoplasmic Sperm Injection (IVF/ICSI) PCOS Patients Polycystic Ovary Syndrome (PCOS) Oocyte Retrieval High Basal LH Medicine R Science Q Lihua Sun Jing Ye Yun Wang Qiuju Chen Renfei Cai Yonglun Fu Hui Tian Qifeng Lyu Xuefeng Lu Yanping Kuang Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
description	Abstract The potential effects of high basal luteinizing hormone (LH) levels on human reproduction were controversial. To demonstrate the effects of elevated basal LH levels on the outcome of patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles, we performed a retrospective data analysis of 1011 polycystic ovarian syndrome (PCOS) patients treated with human menopausal gonadotropin and medroxyprogesterone acetate (hMG + MPA) protocol at our center between Nov. 2013 and Jun. 2017. PCOS patients with elevated basal LH levels had significantly higher LH exposure during the stimulation period. The group with LH ≥ 10 mIU/mL showed a lower mean total hMG dose used but higher numbers of oocytes retrieved, metaphase II oocytes, embryos and top-quality embryos developed than the groups with lower basal LH levels. Moreover, partial correlation analysis showed that the basal LH level was negatively correlated with the total hMG dose but positively correlated with the numbers of oocytes retrieved, metaphase II oocytes, embryos, and top-quality embryos. There were no significant differences in the rates of oocyte retrieval, fertilization, implantation, clinical pregnancy and miscarriage between the groups based on frozen embryo transfer (FET). We concluded that elevated basal LH level does not impair the final outcome of hMG + MPA-treated IVF/ICSI cycles in PCOS women.
format	article
author	Lihua Sun Jing Ye Yun Wang Qiuju Chen Renfei Cai Yonglun Fu Hui Tian Qifeng Lyu Xuefeng Lu Yanping Kuang
author_facet	Lihua Sun Jing Ye Yun Wang Qiuju Chen Renfei Cai Yonglun Fu Hui Tian Qifeng Lyu Xuefeng Lu Yanping Kuang
author_sort	Lihua Sun
title	Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
title_short	Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
title_full	Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
title_fullStr	Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
title_full_unstemmed	Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
title_sort	elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4539208a737143fc81e86fdfcaafe539
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Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles

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