Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial

Although rehydration therapy (RT) has been used to treat animals suffering from viral diarrhea, mortality among farm animals still remains high, as RT alone neither significantly minimizes the duration of the illness nor reduces the looseness of stools. As porcine epidemic diarrhea (PED) is a viral...

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Autores principales:	Takio Inatomi, Takamitsu Tsukahara, Gustavo A. Romero-Pérez, Ryo Inoue
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	porcine epidemic diarrhea rehydration therapy probiotics neonatal piglets Agriculture (General) S1-972
Acceso en línea:	https://doaj.org/article/453dc9cb942f475bb4a88e794f00d998
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spelling	oai:doaj.org-article:453dc9cb942f475bb4a88e794f00d9982021-11-25T15:58:23ZCombined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial10.3390/agriculture111110582077-0472https://doaj.org/article/453dc9cb942f475bb4a88e794f00d9982021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0472/11/11/1058https://doaj.org/toc/2077-0472Although rehydration therapy (RT) has been used to treat animals suffering from viral diarrhea, mortality among farm animals still remains high, as RT alone neither significantly minimizes the duration of the illness nor reduces the looseness of stools. As porcine epidemic diarrhea (PED) is a viral disease and PED treatments are still very limited, vaccination is the common strategy to prevent it. Thus, the aim of the present study was to test whether a combination of RT and probiotics supplementation could help to improve the mortality of suckling piglets kept in a commercial farm and naturally infected with PED virus. Piglets receiving a combination of probiotic supplementation and RT showed improved (<i>p</i> < 0.01) blood parameters such as base excess and bicarbonate ion concentration when compared with untreated control piglets and piglets administered with RT alone. When compared with that of control piglets, mortality during the suckling period was the lowest (<i>p</i> < 0.05) in piglets receiving the combined therapy, but statistically unchanged between piglets receiving either RT or RT and probiotics. Our preliminary results should motivate further research on the use of a combined rehydration and probiotics therapy to reduce mortality in piglets suffering from acute diarrhea.Takio InatomiTakamitsu TsukaharaGustavo A. Romero-PérezRyo InoueMDPI AGarticleporcine epidemic diarrhearehydration therapyprobioticsneonatal pigletsAgriculture (General)S1-972ENAgriculture, Vol 11, Iss 1058, p 1058 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	porcine epidemic diarrhea rehydration therapy probiotics neonatal piglets Agriculture (General) S1-972
spellingShingle	porcine epidemic diarrhea rehydration therapy probiotics neonatal piglets Agriculture (General) S1-972 Takio Inatomi Takamitsu Tsukahara Gustavo A. Romero-Pérez Ryo Inoue Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
description	Although rehydration therapy (RT) has been used to treat animals suffering from viral diarrhea, mortality among farm animals still remains high, as RT alone neither significantly minimizes the duration of the illness nor reduces the looseness of stools. As porcine epidemic diarrhea (PED) is a viral disease and PED treatments are still very limited, vaccination is the common strategy to prevent it. Thus, the aim of the present study was to test whether a combination of RT and probiotics supplementation could help to improve the mortality of suckling piglets kept in a commercial farm and naturally infected with PED virus. Piglets receiving a combination of probiotic supplementation and RT showed improved (<i>p</i> < 0.01) blood parameters such as base excess and bicarbonate ion concentration when compared with untreated control piglets and piglets administered with RT alone. When compared with that of control piglets, mortality during the suckling period was the lowest (<i>p</i> < 0.05) in piglets receiving the combined therapy, but statistically unchanged between piglets receiving either RT or RT and probiotics. Our preliminary results should motivate further research on the use of a combined rehydration and probiotics therapy to reduce mortality in piglets suffering from acute diarrhea.
format	article
author	Takio Inatomi Takamitsu Tsukahara Gustavo A. Romero-Pérez Ryo Inoue
author_facet	Takio Inatomi Takamitsu Tsukahara Gustavo A. Romero-Pérez Ryo Inoue
author_sort	Takio Inatomi
title	Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
title_short	Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
title_full	Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
title_fullStr	Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
title_full_unstemmed	Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial
title_sort	combined therapy of probiotic supplementation and rehydration improves blood dehydration parameters and decreases mortality of neonatal piglets naturally infected with porcine epidemic diarrhea virus: a clinical trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/453dc9cb942f475bb4a88e794f00d998
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Combined Therapy of Probiotic Supplementation and Rehydration Improves Blood Dehydration Parameters and Decreases Mortality of Neonatal Piglets Naturally Infected with Porcine Epidemic Diarrhea Virus: A Clinical Trial

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