Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis
Yunfang Luo,1,* Fang Yu,1,* Xianjing Feng,1 Di Liao,1 Yuanlin Ying,1 Xi Li,1 Qin Huang,1 Zeyu Liu,1 Minping Wei,1 Tingting Zhao,1 Lin Zhang,1 Ruxin Tu,1 Jian Xia1– 3 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China;...
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2021
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oai:doaj.org-article:453f7575a6a54f0682f5231cc1fc4cc72021-12-02T16:58:44ZMolecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis1178-1998https://doaj.org/article/453f7575a6a54f0682f5231cc1fc4cc72021-06-01T00:00:00Zhttps://www.dovepress.com/molecular-biomarkers-associated-with-early-onset-symptomatic-intracran-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Yunfang Luo,1,* Fang Yu,1,* Xianjing Feng,1 Di Liao,1 Yuanlin Ying,1 Xi Li,1 Qin Huang,1 Zeyu Liu,1 Minping Wei,1 Tingting Zhao,1 Lin Zhang,1 Ruxin Tu,1 Jian Xia1– 3 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian XiaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of ChinaTel +86 731 84327216Fax +86 731 84327401. Email xjian1216@csu.edu.cnPurpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention.Patients and Methods: We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤ 60 years old and late-onset sICAS group as age > 60 years old. We collected and compared the demographic data and laboratory results of each group. A bivariate logistic regression model was applied to evaluate the independent molecular biomarkers of early-onset sICAS.Results: A total of 1007 subjects with sICAS were enrolled in this study, comprising 519 patients in the early-onset sICAS group and 488 patients in the late-onset sICAS group. Bivariate logistic regression analysis demonstrated an increased level of white blood cell, platelet, albumin globulin ratio, free triiodothyronine, and a decreased level of total bile acid, urea nitrogen, high-density lipoprotein, homocysteine, and fibrinogen in the early-onset sICAS group when compared to the late-onset group.Conclusion: Our study showed the relevance between early sICAS and circulating levels of different molecular biomarkers. Detection of these related molecular biomarkers may provide a simple way for early sICAS preventions in the future.Keywords: ischemic stroke, symptomatic intracranial atherosclerosis, molecular biomarkersLuo YYu FFeng XLiao DYing YLi XHuang QLiu ZWei MZhao TZhang LTu RXia JDove Medical Pressarticleischemic strokesymptomatic intracranial atherosclerosismolecular biomarkers.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1013-1022 (2021) |
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ischemic stroke symptomatic intracranial atherosclerosis molecular biomarkers. Geriatrics RC952-954.6 |
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ischemic stroke symptomatic intracranial atherosclerosis molecular biomarkers. Geriatrics RC952-954.6 Luo Y Yu F Feng X Liao D Ying Y Li X Huang Q Liu Z Wei M Zhao T Zhang L Tu R Xia J Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| description |
Yunfang Luo,1,* Fang Yu,1,* Xianjing Feng,1 Di Liao,1 Yuanlin Ying,1 Xi Li,1 Qin Huang,1 Zeyu Liu,1 Minping Wei,1 Tingting Zhao,1 Lin Zhang,1 Ruxin Tu,1 Jian Xia1– 3 1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian XiaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of ChinaTel +86 731 84327216Fax +86 731 84327401. Email xjian1216@csu.edu.cnPurpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention.Patients and Methods: We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤ 60 years old and late-onset sICAS group as age > 60 years old. We collected and compared the demographic data and laboratory results of each group. A bivariate logistic regression model was applied to evaluate the independent molecular biomarkers of early-onset sICAS.Results: A total of 1007 subjects with sICAS were enrolled in this study, comprising 519 patients in the early-onset sICAS group and 488 patients in the late-onset sICAS group. Bivariate logistic regression analysis demonstrated an increased level of white blood cell, platelet, albumin globulin ratio, free triiodothyronine, and a decreased level of total bile acid, urea nitrogen, high-density lipoprotein, homocysteine, and fibrinogen in the early-onset sICAS group when compared to the late-onset group.Conclusion: Our study showed the relevance between early sICAS and circulating levels of different molecular biomarkers. Detection of these related molecular biomarkers may provide a simple way for early sICAS preventions in the future.Keywords: ischemic stroke, symptomatic intracranial atherosclerosis, molecular biomarkers |
| format |
article |
| author |
Luo Y Yu F Feng X Liao D Ying Y Li X Huang Q Liu Z Wei M Zhao T Zhang L Tu R Xia J |
| author_facet |
Luo Y Yu F Feng X Liao D Ying Y Li X Huang Q Liu Z Wei M Zhao T Zhang L Tu R Xia J |
| author_sort |
Luo Y |
| title |
Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| title_short |
Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| title_full |
Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| title_fullStr |
Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| title_full_unstemmed |
Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis |
| title_sort |
molecular biomarkers associated with early-onset symptomatic intracranial atherosclerosis |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/453f7575a6a54f0682f5231cc1fc4cc7 |
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