Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution

Biofilm disruption: patterns of weak spots Using air bubbles to disrupt biofilms reveals patterns in biofilm structure and susceptibility to damage that depend on a biofilm’s age. Roman Stocker and colleagues at the Swiss Federal Institute of Technology in Zurich (ETH) used controlled flow of an air...

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Autores principales:	Hongchul Jang, Roberto Rusconi, Roman Stocker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/4540040dfeea4c3aac21ff7c45625dab
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spelling	oai:doaj.org-article:4540040dfeea4c3aac21ff7c45625dab2021-12-02T15:10:26ZBiofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution10.1038/s41522-017-0014-52055-5008https://doaj.org/article/4540040dfeea4c3aac21ff7c45625dab2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0014-5https://doaj.org/toc/2055-5008Biofilm disruption: patterns of weak spots Using air bubbles to disrupt biofilms reveals patterns in biofilm structure and susceptibility to damage that depend on a biofilm’s age. Roman Stocker and colleagues at the Swiss Federal Institute of Technology in Zurich (ETH) used controlled flow of an air bubble to understand mechanical disruption of biofilms of Pseudomonas aeruginosa. This physical assault caused a characteristic pattern of holes in early-stage biofilms, different from the damage pattern in older biofilms. The holes were most likely to occur in regions that were relatively deficient in the polymers released by bacterial cells to form the extracellular structure of the biofilm. These findings highlight the importance of heterogeneities in the structure of biofilms as they form. The researchers suggest more attention should be given to age-related variations in microscale structure when designing strategies to disrupt biofilms.Hongchul JangRoberto RusconiRoman StockerNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Hongchul Jang Roberto Rusconi Roman Stocker Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
description	Biofilm disruption: patterns of weak spots Using air bubbles to disrupt biofilms reveals patterns in biofilm structure and susceptibility to damage that depend on a biofilm’s age. Roman Stocker and colleagues at the Swiss Federal Institute of Technology in Zurich (ETH) used controlled flow of an air bubble to understand mechanical disruption of biofilms of Pseudomonas aeruginosa. This physical assault caused a characteristic pattern of holes in early-stage biofilms, different from the damage pattern in older biofilms. The holes were most likely to occur in regions that were relatively deficient in the polymers released by bacterial cells to form the extracellular structure of the biofilm. These findings highlight the importance of heterogeneities in the structure of biofilms as they form. The researchers suggest more attention should be given to age-related variations in microscale structure when designing strategies to disrupt biofilms.
format	article
author	Hongchul Jang Roberto Rusconi Roman Stocker
author_facet	Hongchul Jang Roberto Rusconi Roman Stocker
author_sort	Hongchul Jang
title	Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
title_short	Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
title_full	Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
title_fullStr	Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
title_full_unstemmed	Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
title_sort	biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4540040dfeea4c3aac21ff7c45625dab
work_keys_str_mv	AT hongchuljang biofilmdisruptionbyanairbubblerevealsheterogeneousagedependentdetachmentpatternsdictatedbyinitialextracellularmatrixdistribution AT robertorusconi biofilmdisruptionbyanairbubblerevealsheterogeneousagedependentdetachmentpatternsdictatedbyinitialextracellularmatrixdistribution AT romanstocker biofilmdisruptionbyanairbubblerevealsheterogeneousagedependentdetachmentpatternsdictatedbyinitialextracellularmatrixdistribution
_version_	1718387685961236480

Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution

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