Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.

<h4>Background</h4>The effects of long-term cigarette smoke exposure on pulmonary physiology and how those effects lead to reduced exercise capacity are not well established.<h4>Methods</h4>We retrospectively analyzed the spirometry, single-breath gas transfer (DLCO), periphe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adil Adatia, Mustafaa Wahab, Izza Shahid, Ali Moinuddin, Kieran J Killian, Imran Satia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4541db08ef15430a8617a52856522627
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4541db08ef15430a8617a52856522627
record_format	dspace
spelling	oai:doaj.org-article:4541db08ef15430a8617a528565226272021-12-02T20:05:18ZEffects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.1932-620310.1371/journal.pone.0250957https://doaj.org/article/4541db08ef15430a8617a528565226272021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250957https://doaj.org/toc/1932-6203<h4>Background</h4>The effects of long-term cigarette smoke exposure on pulmonary physiology and how those effects lead to reduced exercise capacity are not well established.<h4>Methods</h4>We retrospectively analyzed the spirometry, single-breath gas transfer (DLCO), peripheral muscle strength, and maximum exercise capacity data in patients referred to McMaster University Medical Centre for cardiopulmonary exercise testing between 2000 and 2012.<h4>Results</h4>29,441 subjects underwent CPET and had a recorded smoking history [58% male, mean age 51.1 years (S.D.±19.6), BMI 27.4 kg/m2(±5.8)]. 7081 (24%) were current or former smokers and were divided into 4 categories by packs years (mean ±S.D.): <10 (5.8±3.3), 10-20 (17.1±2.9), 20-30 (27.1±2.8), 30-40 (37.3±2.8), and >40 (53.9±12.8). Patients with greater cigarette smoke exposure had lower expiratory flow rates (FEV1, FEF50, FEF75, PEFR), DLCO, and maximum power output (MPO) during exercise. There was no association between smoke exposure and muscle strength. Modeling MPO (kpm/min) output as a function of demographic and physiologic variables showed that the data are well explained by muscle strength (kg), FEV1 (L), and DLCO (mmHg/min/mL) in similar magnitude (MPO = 42.7Quads0.34FEV10.34 * DLCO0.43; r = 0.84).<h4>Conclusions</h4>Long-term cigarette smoke exposure is associated with small airway narrowing and impaired diffusion capacity but not with peripheral muscle weakness. The effects of smoking, age, and gender on maximum power output are mediated by reductions in FEV1, muscle strength and DLCO. Exercise capacity in smokers may benefit from therapies targeting all 3 variables.Adil AdatiaMustafaa WahabIzza ShahidAli MoinuddinKieran J KillianImran SatiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0250957 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adil Adatia Mustafaa Wahab Izza Shahid Ali Moinuddin Kieran J Killian Imran Satia Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
description	<h4>Background</h4>The effects of long-term cigarette smoke exposure on pulmonary physiology and how those effects lead to reduced exercise capacity are not well established.<h4>Methods</h4>We retrospectively analyzed the spirometry, single-breath gas transfer (DLCO), peripheral muscle strength, and maximum exercise capacity data in patients referred to McMaster University Medical Centre for cardiopulmonary exercise testing between 2000 and 2012.<h4>Results</h4>29,441 subjects underwent CPET and had a recorded smoking history [58% male, mean age 51.1 years (S.D.±19.6), BMI 27.4 kg/m2(±5.8)]. 7081 (24%) were current or former smokers and were divided into 4 categories by packs years (mean ±S.D.): <10 (5.8±3.3), 10-20 (17.1±2.9), 20-30 (27.1±2.8), 30-40 (37.3±2.8), and >40 (53.9±12.8). Patients with greater cigarette smoke exposure had lower expiratory flow rates (FEV1, FEF50, FEF75, PEFR), DLCO, and maximum power output (MPO) during exercise. There was no association between smoke exposure and muscle strength. Modeling MPO (kpm/min) output as a function of demographic and physiologic variables showed that the data are well explained by muscle strength (kg), FEV1 (L), and DLCO (mmHg/min/mL) in similar magnitude (MPO = 42.7Quads0.34FEV10.34 * DLCO0.43; r = 0.84).<h4>Conclusions</h4>Long-term cigarette smoke exposure is associated with small airway narrowing and impaired diffusion capacity but not with peripheral muscle weakness. The effects of smoking, age, and gender on maximum power output are mediated by reductions in FEV1, muscle strength and DLCO. Exercise capacity in smokers may benefit from therapies targeting all 3 variables.
format	article
author	Adil Adatia Mustafaa Wahab Izza Shahid Ali Moinuddin Kieran J Killian Imran Satia
author_facet	Adil Adatia Mustafaa Wahab Izza Shahid Ali Moinuddin Kieran J Killian Imran Satia
author_sort	Adil Adatia
title	Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
title_short	Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
title_full	Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
title_fullStr	Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
title_full_unstemmed	Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
title_sort	effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4541db08ef15430a8617a52856522627
work_keys_str_mv	AT adiladatia effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects AT mustafaawahab effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects AT izzashahid effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects AT alimoinuddin effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects AT kieranjkillian effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects AT imransatia effectsofcigarettesmokeexposureonpulmonaryphysiologymusclestrengthandexercisecapacityinaretrospectivecohortwith30000subjects
_version_	1718375477412888576

Effects of cigarette smoke exposure on pulmonary physiology, muscle strength and exercise capacity in a retrospective cohort with 30,000 subjects.

Ejemplares similares