Optical coherence tomography findings of quinine poisoning

John Christoforidis, Robert Ricketts, Theodore Loizos, Susie ChangThe Ohio State University College of Medicine, Columbus, OH, USAPurpose: To report a case of acute quinine poisoning, document acute and chronic macular changes with optical coherence tomography imaging and fluorescein angiography (FA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	John Christoforidis, Robert Ricketts, Theodore Loizos, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4545179dd34c447494532bac23f55623
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4545179dd34c447494532bac23f55623
record_format	dspace
spelling	oai:doaj.org-article:4545179dd34c447494532bac23f556232021-12-02T00:15:10ZOptical coherence tomography findings of quinine poisoning1177-54671177-5483https://doaj.org/article/4545179dd34c447494532bac23f556232011-01-01T00:00:00Zhttp://www.dovepress.com/optical-coherence-tomography-findings-of-quinine-poisoning-a6040https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483John Christoforidis, Robert Ricketts, Theodore Loizos, Susie ChangThe Ohio State University College of Medicine, Columbus, OH, USAPurpose: To report a case of acute quinine poisoning, document acute and chronic macular changes with optical coherence tomography imaging and fluorescein angiography (FA), and to review the literature on ocular toxicity of quinine.Methods: A 32-year-old white female presented to our Emergency Department after ingesting over 7.5 g of quinine. She underwent a complete ophthalmologic examination, fluorescein angiography, Stratus time-domain optical coherence tomography (OCT), and electroretinography at 72 hours and 15 months postingestion. Stratus time-domain and Cirrus spectral-domain OCT, fundus autofluorescence, and FA were obtained at 28 months postingestion.Results: Fluorescein angiography at 72 hours postingestion revealed normal filling times and vasculature. OCT showed marked thickening of the inner retina bilaterally. At 15 and 28 months follow-up, fundus photography and fluorescein angiography demonstrated optic nerve pallor, severely attenuated retinal vessels while OCT showed inner retinal atrophy. Fundus autofluorescence did not reveal any retinal pigmentary abnormalities.Conclusions: Quinine toxicity as seen by OCT reveals increased thickness with inner retinal hyperreflectivity acutely with development of significant retinal atrophy in the long-term. Fundus autofluorescence reveals an intact retinal pigment epithelial layer at 28 months. These findings suggest that quinine poisoning may produce a direct toxic effect on the inner retina in the acute phase resulting in long-term retinal atrophy.Keywords: retinal, optical coherence tomography, quinine toxicity&nbsp; John ChristoforidisRobert RickettsTheodore Loizoset alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 75-80 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 John Christoforidis Robert Ricketts Theodore Loizos et al Optical coherence tomography findings of quinine poisoning
description	John Christoforidis, Robert Ricketts, Theodore Loizos, Susie ChangThe Ohio State University College of Medicine, Columbus, OH, USAPurpose: To report a case of acute quinine poisoning, document acute and chronic macular changes with optical coherence tomography imaging and fluorescein angiography (FA), and to review the literature on ocular toxicity of quinine.Methods: A 32-year-old white female presented to our Emergency Department after ingesting over 7.5 g of quinine. She underwent a complete ophthalmologic examination, fluorescein angiography, Stratus time-domain optical coherence tomography (OCT), and electroretinography at 72 hours and 15 months postingestion. Stratus time-domain and Cirrus spectral-domain OCT, fundus autofluorescence, and FA were obtained at 28 months postingestion.Results: Fluorescein angiography at 72 hours postingestion revealed normal filling times and vasculature. OCT showed marked thickening of the inner retina bilaterally. At 15 and 28 months follow-up, fundus photography and fluorescein angiography demonstrated optic nerve pallor, severely attenuated retinal vessels while OCT showed inner retinal atrophy. Fundus autofluorescence did not reveal any retinal pigmentary abnormalities.Conclusions: Quinine toxicity as seen by OCT reveals increased thickness with inner retinal hyperreflectivity acutely with development of significant retinal atrophy in the long-term. Fundus autofluorescence reveals an intact retinal pigment epithelial layer at 28 months. These findings suggest that quinine poisoning may produce a direct toxic effect on the inner retina in the acute phase resulting in long-term retinal atrophy.Keywords: retinal, optical coherence tomography, quinine toxicity&nbsp;
format	article
author	John Christoforidis Robert Ricketts Theodore Loizos et al
author_facet	John Christoforidis Robert Ricketts Theodore Loizos et al
author_sort	John Christoforidis
title	Optical coherence tomography findings of quinine poisoning
title_short	Optical coherence tomography findings of quinine poisoning
title_full	Optical coherence tomography findings of quinine poisoning
title_fullStr	Optical coherence tomography findings of quinine poisoning
title_full_unstemmed	Optical coherence tomography findings of quinine poisoning
title_sort	optical coherence tomography findings of quinine poisoning
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/4545179dd34c447494532bac23f55623
work_keys_str_mv	AT johnchristoforidis opticalcoherencetomographyfindingsofquininepoisoning AT robertricketts opticalcoherencetomographyfindingsofquininepoisoning AT theodoreloizos opticalcoherencetomographyfindingsofquininepoisoning AT etal opticalcoherencetomographyfindingsofquininepoisoning
_version_	1718403861727674368

Optical coherence tomography findings of quinine poisoning

Ejemplares similares