Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and find that the compromised blood cell-forming pote...

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Autores principales:	Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45468cb969c947199083e10e2b6af32d
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spelling	oai:doaj.org-article:45468cb969c947199083e10e2b6af32d2021-12-02T15:38:32ZClonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate10.1038/ncomms145332041-1723https://doaj.org/article/45468cb969c947199083e10e2b6af32d2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14533https://doaj.org/toc/2041-1723Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and find that the compromised blood cell-forming potential of individual and functionally defined aged HSCs can be reset by reprogramming.Martin WahlestedtEva ErlandssonTrine KristiansenRong LuCord BrakebuschIrving L. WeissmanJoan YuanJavier Martin-GonzalezDavid BryderNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Wahlestedt Eva Erlandsson Trine Kristiansen Rong Lu Cord Brakebusch Irving L. Weissman Joan Yuan Javier Martin-Gonzalez David Bryder Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
description	Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and find that the compromised blood cell-forming potential of individual and functionally defined aged HSCs can be reset by reprogramming.
format	article
author	Martin Wahlestedt Eva Erlandsson Trine Kristiansen Rong Lu Cord Brakebusch Irving L. Weissman Joan Yuan Javier Martin-Gonzalez David Bryder
author_facet	Martin Wahlestedt Eva Erlandsson Trine Kristiansen Rong Lu Cord Brakebusch Irving L. Weissman Joan Yuan Javier Martin-Gonzalez David Bryder
author_sort	Martin Wahlestedt
title	Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
title_short	Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
title_full	Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
title_fullStr	Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
title_full_unstemmed	Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
title_sort	clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/45468cb969c947199083e10e2b6af32d
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Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

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