Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and find that the compromised blood cell-forming pote...

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Autores principales: Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/45468cb969c947199083e10e2b6af32d
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