A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepat...

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Autores principales: Emilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire, Mirian Fernández-Vaquero, Tobias Riedl, Xiaochen Sun, Hadassa Hirschfield, Frank Jühling, Shijia Zhu, Natascha Roehlen, Clara Ponsolles, Laura Heydmann, Antonio Saviano, Tongqi Qian, Anu Venkatesh, Joachim Lupberger, Eloi R. Verrier, Mozhdeh Sojoodi, Marine A. Oudot, François H. T. Duong, Ricard Masia, Lan Wei, Christine Thumann, Sarah C. Durand, Victor González-Motos, Danijela Heide, Jenny Hetzer, Shigeki Nakagawa, Atsushi Ono, Won-Min Song, Takaaki Higashi, Roberto Sanchez, Rosa S. Kim, C. Billie Bian, Karun Kiani, Tom Croonenborghs, Aravind Subramanian, Raymond T. Chung, Beate K. Straub, Detlef Schuppan, Maliki Ankavay, Laurence Cocquerel, Evelyne Schaeffer, Nicolas Goossens, Anna P. Koh, Milind Mahajan, Venugopalan D. Nair, Ganesh Gunasekaran, Myron E. Schwartz, Nabeel Bardeesy, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, Emanuele Felli, Patrick Pessaux, Kenneth K. Tanabe, Mathias Heikenwälder, Catherine Schuster, Nathalie Pochet, Mirjam B. Zeisel, Bryan C. Fuchs, Yujin Hoshida, Thomas F. Baumert
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e3
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spelling oai:doaj.org-article:454d7d31ae1e40b7812cd73b90a2e7e32021-12-02T18:33:47ZA human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery10.1038/s41467-021-25468-92041-1723https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25468-9https://doaj.org/toc/2041-1723Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.Emilie CrouchetSimonetta BandieraNaoto FujiwaraShen LiHussein El SaghireMirian Fernández-VaqueroTobias RiedlXiaochen SunHadassa HirschfieldFrank JühlingShijia ZhuNatascha RoehlenClara PonsollesLaura HeydmannAntonio SavianoTongqi QianAnu VenkateshJoachim LupbergerEloi R. VerrierMozhdeh SojoodiMarine A. OudotFrançois H. T. DuongRicard MasiaLan WeiChristine ThumannSarah C. DurandVictor González-MotosDanijela HeideJenny HetzerShigeki NakagawaAtsushi OnoWon-Min SongTakaaki HigashiRoberto SanchezRosa S. KimC. Billie BianKarun KianiTom CroonenborghsAravind SubramanianRaymond T. ChungBeate K. StraubDetlef SchuppanMaliki AnkavayLaurence CocquerelEvelyne SchaefferNicolas GoossensAnna P. KohMilind MahajanVenugopalan D. NairGanesh GunasekaranMyron E. SchwartzNabeel BardeesyAlex K. ShalekOrit Rozenblatt-RosenAviv RegevEmanuele FelliPatrick PessauxKenneth K. TanabeMathias HeikenwälderCatherine SchusterNathalie PochetMirjam B. ZeiselBryan C. FuchsYujin HoshidaThomas F. BaumertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emilie Crouchet
Simonetta Bandiera
Naoto Fujiwara
Shen Li
Hussein El Saghire
Mirian Fernández-Vaquero
Tobias Riedl
Xiaochen Sun
Hadassa Hirschfield
Frank Jühling
Shijia Zhu
Natascha Roehlen
Clara Ponsolles
Laura Heydmann
Antonio Saviano
Tongqi Qian
Anu Venkatesh
Joachim Lupberger
Eloi R. Verrier
Mozhdeh Sojoodi
Marine A. Oudot
François H. T. Duong
Ricard Masia
Lan Wei
Christine Thumann
Sarah C. Durand
Victor González-Motos
Danijela Heide
Jenny Hetzer
Shigeki Nakagawa
Atsushi Ono
Won-Min Song
Takaaki Higashi
Roberto Sanchez
Rosa S. Kim
C. Billie Bian
Karun Kiani
Tom Croonenborghs
Aravind Subramanian
Raymond T. Chung
Beate K. Straub
Detlef Schuppan
Maliki Ankavay
Laurence Cocquerel
Evelyne Schaeffer
Nicolas Goossens
Anna P. Koh
Milind Mahajan
Venugopalan D. Nair
Ganesh Gunasekaran
Myron E. Schwartz
Nabeel Bardeesy
Alex K. Shalek
Orit Rozenblatt-Rosen
Aviv Regev
Emanuele Felli
Patrick Pessaux
Kenneth K. Tanabe
Mathias Heikenwälder
Catherine Schuster
Nathalie Pochet
Mirjam B. Zeisel
Bryan C. Fuchs
Yujin Hoshida
Thomas F. Baumert
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
description Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.
format article
author Emilie Crouchet
Simonetta Bandiera
Naoto Fujiwara
Shen Li
Hussein El Saghire
Mirian Fernández-Vaquero
Tobias Riedl
Xiaochen Sun
Hadassa Hirschfield
Frank Jühling
Shijia Zhu
Natascha Roehlen
Clara Ponsolles
Laura Heydmann
Antonio Saviano
Tongqi Qian
Anu Venkatesh
Joachim Lupberger
Eloi R. Verrier
Mozhdeh Sojoodi
Marine A. Oudot
François H. T. Duong
Ricard Masia
Lan Wei
Christine Thumann
Sarah C. Durand
Victor González-Motos
Danijela Heide
Jenny Hetzer
Shigeki Nakagawa
Atsushi Ono
Won-Min Song
Takaaki Higashi
Roberto Sanchez
Rosa S. Kim
C. Billie Bian
Karun Kiani
Tom Croonenborghs
Aravind Subramanian
Raymond T. Chung
Beate K. Straub
Detlef Schuppan
Maliki Ankavay
Laurence Cocquerel
Evelyne Schaeffer
Nicolas Goossens
Anna P. Koh
Milind Mahajan
Venugopalan D. Nair
Ganesh Gunasekaran
Myron E. Schwartz
Nabeel Bardeesy
Alex K. Shalek
Orit Rozenblatt-Rosen
Aviv Regev
Emanuele Felli
Patrick Pessaux
Kenneth K. Tanabe
Mathias Heikenwälder
Catherine Schuster
Nathalie Pochet
Mirjam B. Zeisel
Bryan C. Fuchs
Yujin Hoshida
Thomas F. Baumert
author_facet Emilie Crouchet
Simonetta Bandiera
Naoto Fujiwara
Shen Li
Hussein El Saghire
Mirian Fernández-Vaquero
Tobias Riedl
Xiaochen Sun
Hadassa Hirschfield
Frank Jühling
Shijia Zhu
Natascha Roehlen
Clara Ponsolles
Laura Heydmann
Antonio Saviano
Tongqi Qian
Anu Venkatesh
Joachim Lupberger
Eloi R. Verrier
Mozhdeh Sojoodi
Marine A. Oudot
François H. T. Duong
Ricard Masia
Lan Wei
Christine Thumann
Sarah C. Durand
Victor González-Motos
Danijela Heide
Jenny Hetzer
Shigeki Nakagawa
Atsushi Ono
Won-Min Song
Takaaki Higashi
Roberto Sanchez
Rosa S. Kim
C. Billie Bian
Karun Kiani
Tom Croonenborghs
Aravind Subramanian
Raymond T. Chung
Beate K. Straub
Detlef Schuppan
Maliki Ankavay
Laurence Cocquerel
Evelyne Schaeffer
Nicolas Goossens
Anna P. Koh
Milind Mahajan
Venugopalan D. Nair
Ganesh Gunasekaran
Myron E. Schwartz
Nabeel Bardeesy
Alex K. Shalek
Orit Rozenblatt-Rosen
Aviv Regev
Emanuele Felli
Patrick Pessaux
Kenneth K. Tanabe
Mathias Heikenwälder
Catherine Schuster
Nathalie Pochet
Mirjam B. Zeisel
Bryan C. Fuchs
Yujin Hoshida
Thomas F. Baumert
author_sort Emilie Crouchet
title A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
title_short A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
title_full A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
title_fullStr A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
title_full_unstemmed A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
title_sort human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e3
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