Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study

Background: Hepatocellular Carcinoma (HCC) is the most prevalent liver cancer with high mortality. Early detection is important for better patient outcomes. The aim of this study was to explore clinical manifestations and laboratory examinations among HCC patients in a tertiary care facility. Metho...

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Autores principales:	Grace Amanda Maharani, Eka Surya Nugraha, Adhi Kristianto Sugianli
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Padjadjaran 2021
Materias:	clinical manifestation, hepatocellular carcinoma, supporting examination Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/454f31afe11341f4994c1c2c0585a8d6
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spelling	oai:doaj.org-article:454f31afe11341f4994c1c2c0585a8d62021-11-17T05:18:21ZClinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study2337-433010.15850/amj.v8n3.2333https://doaj.org/article/454f31afe11341f4994c1c2c0585a8d62021-09-01T00:00:00Zhttp://journal.fk.unpad.ac.id/index.php/amj/article/view/2333https://doaj.org/toc/2337-4330Background: Hepatocellular Carcinoma (HCC) is the most prevalent liver cancer with high mortality. Early detection is important for better patient outcomes. The aim of this study was to explore clinical manifestations and laboratory examinations among HCC patients in a tertiary care facility. Methods: This was a cross-sectional descriptive study with a total sampling method, reviewing the medical record of patients with HCC in the Outpatient Clinic of Dr. Hasan Sadikin General Hospital between January to December 2019. Clinical manifestations, laboratory findings, and imaging results data were collected. Results: Of the 112 HCC patients included in this study, the HCC findings among new patients at the outpatient clinic were 8.4%, with hepatitis B (80.8%) as the major etiology. Complaints of abdominal pain (65.2%) was frequent. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased in 89.8% and 67% of patients, as well as total bilirubin levels in 58.8% of patients. In contrast, hemoglobin and albumin levels decreased in 55.3% and 78.1% of patients, respectively. The characteristics of tumor were mainly multinodular, with a size of 3-10 cm. Conclusions: The annual proportion of HCC in Dr. Hasan Sadikin General Hospital in 2019 is 8.4% among all outpatient gastrointestinal and hepatology cases, with hepatitis B as the most common etiology. Abdominal pain is the predominantly prevalent clinical manifestation with increased ALT and AST levels.Grace Amanda MaharaniEka Surya NugrahaAdhi Kristianto SugianliUniversitas Padjadjaranarticleclinical manifestation, hepatocellular carcinoma, supporting examinationMedicineRMedicine (General)R5-920ENAlthea Medical Journal, Vol 8, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical manifestation, hepatocellular carcinoma, supporting examination Medicine R Medicine (General) R5-920
spellingShingle	clinical manifestation, hepatocellular carcinoma, supporting examination Medicine R Medicine (General) R5-920 Grace Amanda Maharani Eka Surya Nugraha Adhi Kristianto Sugianli Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
description	Background: Hepatocellular Carcinoma (HCC) is the most prevalent liver cancer with high mortality. Early detection is important for better patient outcomes. The aim of this study was to explore clinical manifestations and laboratory examinations among HCC patients in a tertiary care facility. Methods: This was a cross-sectional descriptive study with a total sampling method, reviewing the medical record of patients with HCC in the Outpatient Clinic of Dr. Hasan Sadikin General Hospital between January to December 2019. Clinical manifestations, laboratory findings, and imaging results data were collected. Results: Of the 112 HCC patients included in this study, the HCC findings among new patients at the outpatient clinic were 8.4%, with hepatitis B (80.8%) as the major etiology. Complaints of abdominal pain (65.2%) was frequent. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased in 89.8% and 67% of patients, as well as total bilirubin levels in 58.8% of patients. In contrast, hemoglobin and albumin levels decreased in 55.3% and 78.1% of patients, respectively. The characteristics of tumor were mainly multinodular, with a size of 3-10 cm. Conclusions: The annual proportion of HCC in Dr. Hasan Sadikin General Hospital in 2019 is 8.4% among all outpatient gastrointestinal and hepatology cases, with hepatitis B as the most common etiology. Abdominal pain is the predominantly prevalent clinical manifestation with increased ALT and AST levels.
format	article
author	Grace Amanda Maharani Eka Surya Nugraha Adhi Kristianto Sugianli
author_facet	Grace Amanda Maharani Eka Surya Nugraha Adhi Kristianto Sugianli
author_sort	Grace Amanda Maharani
title	Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
title_short	Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
title_full	Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
title_fullStr	Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
title_full_unstemmed	Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study
title_sort	clinical manifestations and laboratory examination findings of hepatocellular carcinoma at a tertiary care facility in bandung: an annual observation study
publisher	Universitas Padjadjaran
publishDate	2021
url	https://doaj.org/article/454f31afe11341f4994c1c2c0585a8d6
work_keys_str_mv	AT graceamandamaharani clinicalmanifestationsandlaboratoryexaminationfindingsofhepatocellularcarcinomaatatertiarycarefacilityinbandunganannualobservationstudy AT ekasuryanugraha clinicalmanifestationsandlaboratoryexaminationfindingsofhepatocellularcarcinomaatatertiarycarefacilityinbandunganannualobservationstudy AT adhikristiantosugianli clinicalmanifestationsandlaboratoryexaminationfindingsofhepatocellularcarcinomaatatertiarycarefacilityinbandunganannualobservationstudy
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Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study

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