Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study

Abstract Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ka Chun Chong, Chi Zhang, Katherine Min Jia, Benny Chung Ying Zee, Tongyong Luo, Lei Wang, Greta Chun Huen Tam, Riyang Sun, Maggie Haitian Wang, Xuhua Guan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Supplementary Immunization Activities (SIAs) Measles Control Routine Immunization Varying Coverage Levels Baseline Scenario Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45525336f54f40209e06c5cff3e6d303
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:45525336f54f40209e06c5cff3e6d303
record_format	dspace
spelling	oai:doaj.org-article:45525336f54f40209e06c5cff3e6d3032021-12-02T15:08:25ZTargeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study10.1038/s41598-018-34461-02045-2322https://doaj.org/article/45525336f54f40209e06c5cff3e6d3032018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34461-0https://doaj.org/toc/2045-2322Abstract Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified susceptible-exposed-infectious-recovered model using a recently published contact matrix to depict measles transmissions between individuals in seven age groups. Hubei, a high measles-incidence province in central China, was the selected setting. The baseline scenario was calibrated by fitting with the 2012–2015 age-stratified incidence data. SIAs targeting multiple age groups were simulated. Adult-targeted (>29 years) two-year SIA cycles produced the greatest annual incidence rate decrease, reducing incidences by half over a long timespan with 90% coverage levels. Incidences could remain below 10/100,000 until 2030 if SIAs were provided to individuals ≥6 years old with at least 50% coverage. These findings will help officials prioritize supplementary vaccination strategies. Public health officials in China should consider adult-to-adult transmissions and provide adult-targeted SIAs. Although officials have reported approximately 90% SIA coverage in the past, SIAs for the adult population should be provided on shorter intervals, particularly for the aging population with decreased immunity.Ka Chun ChongChi ZhangKatherine Min JiaBenny Chung Ying ZeeTongyong LuoLei WangGreta Chun Huen TamRiyang SunMaggie Haitian WangXuhua GuanNature PortfolioarticleSupplementary Immunization Activities (SIAs)Measles ControlRoutine ImmunizationVarying Coverage LevelsBaseline ScenarioMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Supplementary Immunization Activities (SIAs) Measles Control Routine Immunization Varying Coverage Levels Baseline Scenario Medicine R Science Q
spellingShingle	Supplementary Immunization Activities (SIAs) Measles Control Routine Immunization Varying Coverage Levels Baseline Scenario Medicine R Science Q Ka Chun Chong Chi Zhang Katherine Min Jia Benny Chung Ying Zee Tongyong Luo Lei Wang Greta Chun Huen Tam Riyang Sun Maggie Haitian Wang Xuhua Guan Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
description	Abstract Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified susceptible-exposed-infectious-recovered model using a recently published contact matrix to depict measles transmissions between individuals in seven age groups. Hubei, a high measles-incidence province in central China, was the selected setting. The baseline scenario was calibrated by fitting with the 2012–2015 age-stratified incidence data. SIAs targeting multiple age groups were simulated. Adult-targeted (>29 years) two-year SIA cycles produced the greatest annual incidence rate decrease, reducing incidences by half over a long timespan with 90% coverage levels. Incidences could remain below 10/100,000 until 2030 if SIAs were provided to individuals ≥6 years old with at least 50% coverage. These findings will help officials prioritize supplementary vaccination strategies. Public health officials in China should consider adult-to-adult transmissions and provide adult-targeted SIAs. Although officials have reported approximately 90% SIA coverage in the past, SIAs for the adult population should be provided on shorter intervals, particularly for the aging population with decreased immunity.
format	article
author	Ka Chun Chong Chi Zhang Katherine Min Jia Benny Chung Ying Zee Tongyong Luo Lei Wang Greta Chun Huen Tam Riyang Sun Maggie Haitian Wang Xuhua Guan
author_facet	Ka Chun Chong Chi Zhang Katherine Min Jia Benny Chung Ying Zee Tongyong Luo Lei Wang Greta Chun Huen Tam Riyang Sun Maggie Haitian Wang Xuhua Guan
author_sort	Ka Chun Chong
title	Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
title_short	Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
title_full	Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
title_fullStr	Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
title_full_unstemmed	Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study
title_sort	targeting adults for supplementary immunization activities of measles control in central china: a mathematical modelling study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/45525336f54f40209e06c5cff3e6d303
work_keys_str_mv	AT kachunchong targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT chizhang targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT katherineminjia targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT bennychungyingzee targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT tongyongluo targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT leiwang targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT gretachunhuentam targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT riyangsun targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT maggiehaitianwang targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy AT xuhuaguan targetingadultsforsupplementaryimmunizationactivitiesofmeaslescontrolincentralchinaamathematicalmodellingstudy
_version_	1718388118099329024

Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study

Ejemplares similares