Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia

Abstract Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) were fabricated and were expected to act as carriers for controlled drug delivery/release, imaging and local heating in biological systems. Adsorption of rhodamine B, sulfonated aluminum phthalocyanine and hy...

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Autores principales:	Vladimir Hovhannisyan, Katarina Siposova, Andrey Musatov, Shean-Jen Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4554b6ea46cd48b9b575b374a175020b
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spelling	oai:doaj.org-article:4554b6ea46cd48b9b575b374a175020b2021-12-02T13:20:12ZDevelopment of multifunctional nanocomposites for controlled drug delivery and hyperthermia10.1038/s41598-021-84927-x2045-2322https://doaj.org/article/4554b6ea46cd48b9b575b374a175020b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84927-xhttps://doaj.org/toc/2045-2322Abstract Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) were fabricated and were expected to act as carriers for controlled drug delivery/release, imaging and local heating in biological systems. Adsorption of rhodamine B, sulfonated aluminum phthalocyanine and hypericin by magnetic CZ nano/micro-particles was investigated, as was the release of hypericin. Using an alternating magnetic field, local temperature increase by 10 °C in animal tissue with injected magnetic CZ particles was demonstrated. In addition, the CZ-based particles have been found to exhibit an anti-amyloidogenic effect on the amyloid aggregation of insulin and lysozyme in a dose- and temperature-dependent manner. Therefore, the mesoporous structure of CZ particles provided a unique platform for preparation of multifunctional magnetic and optical probes suitable for optical imaging, MRI, thermo- and phototherapy and as effective containers for controlled drug delivery. We concluded that magnetic CZ nano/micro-particles could be evaluated for further application in cancer hyperthermia therapy and as anti-amyloidogenic agents.Vladimir HovhannisyanKatarina SiposovaAndrey MusatovShean-Jen ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vladimir Hovhannisyan Katarina Siposova Andrey Musatov Shean-Jen Chen Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
description	Abstract Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) were fabricated and were expected to act as carriers for controlled drug delivery/release, imaging and local heating in biological systems. Adsorption of rhodamine B, sulfonated aluminum phthalocyanine and hypericin by magnetic CZ nano/micro-particles was investigated, as was the release of hypericin. Using an alternating magnetic field, local temperature increase by 10 °C in animal tissue with injected magnetic CZ particles was demonstrated. In addition, the CZ-based particles have been found to exhibit an anti-amyloidogenic effect on the amyloid aggregation of insulin and lysozyme in a dose- and temperature-dependent manner. Therefore, the mesoporous structure of CZ particles provided a unique platform for preparation of multifunctional magnetic and optical probes suitable for optical imaging, MRI, thermo- and phototherapy and as effective containers for controlled drug delivery. We concluded that magnetic CZ nano/micro-particles could be evaluated for further application in cancer hyperthermia therapy and as anti-amyloidogenic agents.
format	article
author	Vladimir Hovhannisyan Katarina Siposova Andrey Musatov Shean-Jen Chen
author_facet	Vladimir Hovhannisyan Katarina Siposova Andrey Musatov Shean-Jen Chen
author_sort	Vladimir Hovhannisyan
title	Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
title_short	Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
title_full	Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
title_fullStr	Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
title_full_unstemmed	Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
title_sort	development of multifunctional nanocomposites for controlled drug delivery and hyperthermia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4554b6ea46cd48b9b575b374a175020b
work_keys_str_mv	AT vladimirhovhannisyan developmentofmultifunctionalnanocompositesforcontrolleddrugdeliveryandhyperthermia AT katarinasiposova developmentofmultifunctionalnanocompositesforcontrolleddrugdeliveryandhyperthermia AT andreymusatov developmentofmultifunctionalnanocompositesforcontrolleddrugdeliveryandhyperthermia AT sheanjenchen developmentofmultifunctionalnanocompositesforcontrolleddrugdeliveryandhyperthermia
_version_	1718393206485286912

Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia

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