ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL

Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated...

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Autores principales:	N. A. Ilyina, E. V. Goiman, O. T. Kudaeva, O. P. Kolesnikova, V. S. Kozhevnikov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	ртпх гзт антиэрготипический ответ активированные спленоциты Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4557b1bd745244b19723be9fc207990e
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spelling	oai:doaj.org-article:4557b1bd745244b19723be9fc207990e2021-11-18T08:03:39ZANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL1563-06252313-741X10.15789/1563-0625-2011-1-29-34https://doaj.org/article/4557b1bd745244b19723be9fc207990e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/280https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction.DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics. (Med. Immunol., 2011, vol. 13, N 1, pp 29-34)N. A. IlyinaE. V. GoimanO. T. KudaevaO. P. KolesnikovaV. S. KozhevnikovSPb RAACIarticleртпхгзтантиэрготипический ответактивированные спленоцитыImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 29-34 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	ртпх гзт антиэрготипический ответ активированные спленоциты Immunologic diseases. Allergy RC581-607
spellingShingle	ртпх гзт антиэрготипический ответ активированные спленоциты Immunologic diseases. Allergy RC581-607 N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
description	Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction.DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics. (Med. Immunol., 2011, vol. 13, N 1, pp 29-34)
format	article
author	N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov
author_facet	N. A. Ilyina E. V. Goiman O. T. Kudaeva O. P. Kolesnikova V. S. Kozhevnikov
author_sort	N. A. Ilyina
title	ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
title_short	ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
title_full	ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
title_fullStr	ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
title_full_unstemmed	ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
title_sort	anti-ergotypic response: role in normal immune response and autoimmune pathology in experimental model
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/4557b1bd745244b19723be9fc207990e
work_keys_str_mv	AT nailyina antiergotypicresponseroleinnormalimmuneresponseandautoimmunepathologyinexperimentalmodel AT evgoiman antiergotypicresponseroleinnormalimmuneresponseandautoimmunepathologyinexperimentalmodel AT otkudaeva antiergotypicresponseroleinnormalimmuneresponseandautoimmunepathologyinexperimentalmodel AT opkolesnikova antiergotypicresponseroleinnormalimmuneresponseandautoimmunepathologyinexperimentalmodel AT vskozhevnikov antiergotypicresponseroleinnormalimmuneresponseandautoimmunepathologyinexperimentalmodel
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ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL

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