Observing Protein One-Dimensional Sliding: Methodology and Biological Significance

One-dimensional (1D) sliding of DNA-binding proteins has been observed by numerous kinetic studies. It appears that many of these sliding events play important roles in a wide range of biological processes. However, one challenge is to determine the physiological relevance of these motions in the co...

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Autores principales:	Xiao-Wen Yang, Jiaquan Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA-binding protein one-dimensional sliding single molecule Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4558259f726b4d95a380b9fcbb640074
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spelling	oai:doaj.org-article:4558259f726b4d95a380b9fcbb6400742021-11-25T16:52:51ZObserving Protein One-Dimensional Sliding: Methodology and Biological Significance10.3390/biom111116182218-273Xhttps://doaj.org/article/4558259f726b4d95a380b9fcbb6400742021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1618https://doaj.org/toc/2218-273XOne-dimensional (1D) sliding of DNA-binding proteins has been observed by numerous kinetic studies. It appears that many of these sliding events play important roles in a wide range of biological processes. However, one challenge is to determine the physiological relevance of these motions in the context of the protein’s biological function. Here, we discuss methods of measuring protein 1D sliding by highlighting the single-molecule approaches that are capable of visualizing particle movement in real time. We also present recent findings that show how protein sliding contributes to function.Xiao-Wen YangJiaquan LiuMDPI AGarticleDNA-binding proteinone-dimensional slidingsingle moleculeMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1618, p 1618 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA-binding protein one-dimensional sliding single molecule Microbiology QR1-502
spellingShingle	DNA-binding protein one-dimensional sliding single molecule Microbiology QR1-502 Xiao-Wen Yang Jiaquan Liu Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
description	One-dimensional (1D) sliding of DNA-binding proteins has been observed by numerous kinetic studies. It appears that many of these sliding events play important roles in a wide range of biological processes. However, one challenge is to determine the physiological relevance of these motions in the context of the protein’s biological function. Here, we discuss methods of measuring protein 1D sliding by highlighting the single-molecule approaches that are capable of visualizing particle movement in real time. We also present recent findings that show how protein sliding contributes to function.
format	article
author	Xiao-Wen Yang Jiaquan Liu
author_facet	Xiao-Wen Yang Jiaquan Liu
author_sort	Xiao-Wen Yang
title	Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
title_short	Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
title_full	Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
title_fullStr	Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
title_full_unstemmed	Observing Protein One-Dimensional Sliding: Methodology and Biological Significance
title_sort	observing protein one-dimensional sliding: methodology and biological significance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4558259f726b4d95a380b9fcbb640074
work_keys_str_mv	AT xiaowenyang observingproteinonedimensionalslidingmethodologyandbiologicalsignificance AT jiaquanliu observingproteinonedimensionalslidingmethodologyandbiologicalsignificance
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Observing Protein One-Dimensional Sliding: Methodology and Biological Significance

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