Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression

Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and the inhibition of this ERG/AR transcriptional circ...

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Autores principales:	Sakshi Goel, Vipul Bhatia, Sushmita Kundu, Tanay Biswas, Shannon Carskadon, Nilesh Gupta, Mohammad Asim, Colm Morrissey, Nallasivam Palanisamy, Bushra Ateeq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/455b94e4205c4b25adcdd9e6f04d6ae9
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spelling	oai:doaj.org-article:455b94e4205c4b25adcdd9e6f04d6ae92021-12-02T17:42:11ZTranscriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression10.1038/s41467-021-25623-22041-1723https://doaj.org/article/455b94e4205c4b25adcdd9e6f04d6ae92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25623-2https://doaj.org/toc/2041-1723Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and the inhibition of this ERG/AR transcriptional circuitry with a BET inhibitor reduces the oncogenic effects of DLX1.Sakshi GoelVipul BhatiaSushmita KunduTanay BiswasShannon CarskadonNilesh GuptaMohammad AsimColm MorrisseyNallasivam PalanisamyBushra AteeqNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sakshi Goel Vipul Bhatia Sushmita Kundu Tanay Biswas Shannon Carskadon Nilesh Gupta Mohammad Asim Colm Morrissey Nallasivam Palanisamy Bushra Ateeq Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
description	Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and the inhibition of this ERG/AR transcriptional circuitry with a BET inhibitor reduces the oncogenic effects of DLX1.
format	article
author	Sakshi Goel Vipul Bhatia Sushmita Kundu Tanay Biswas Shannon Carskadon Nilesh Gupta Mohammad Asim Colm Morrissey Nallasivam Palanisamy Bushra Ateeq
author_facet	Sakshi Goel Vipul Bhatia Sushmita Kundu Tanay Biswas Shannon Carskadon Nilesh Gupta Mohammad Asim Colm Morrissey Nallasivam Palanisamy Bushra Ateeq
author_sort	Sakshi Goel
title	Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
title_short	Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
title_full	Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
title_fullStr	Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
title_full_unstemmed	Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression
title_sort	transcriptional network involving erg and ar orchestrates distal-less homeobox-1 mediated prostate cancer progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/455b94e4205c4b25adcdd9e6f04d6ae9
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Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression

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