How cancer cells remodel lipid metabolism: strategies targeting transcription factors

Abstract Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance...

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Autores principales:	Do-Won Jeong, Seulbee Lee, Yang-Sook Chun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lipid metabolism Transcription factor Cancer Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/455c5ff4664c4db8b9869f297a4946e8
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spelling	oai:doaj.org-article:455c5ff4664c4db8b9869f297a4946e82021-11-14T12:39:49ZHow cancer cells remodel lipid metabolism: strategies targeting transcription factors10.1186/s12944-021-01593-81476-511Xhttps://doaj.org/article/455c5ff4664c4db8b9869f297a4946e82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01593-8https://doaj.org/toc/1476-511XAbstract Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy.Do-Won JeongSeulbee LeeYang-Sook ChunBMCarticleLipid metabolismTranscription factorCancerNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lipid metabolism Transcription factor Cancer Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Lipid metabolism Transcription factor Cancer Nutritional diseases. Deficiency diseases RC620-627 Do-Won Jeong Seulbee Lee Yang-Sook Chun How cancer cells remodel lipid metabolism: strategies targeting transcription factors
description	Abstract Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy.
format	article
author	Do-Won Jeong Seulbee Lee Yang-Sook Chun
author_facet	Do-Won Jeong Seulbee Lee Yang-Sook Chun
author_sort	Do-Won Jeong
title	How cancer cells remodel lipid metabolism: strategies targeting transcription factors
title_short	How cancer cells remodel lipid metabolism: strategies targeting transcription factors
title_full	How cancer cells remodel lipid metabolism: strategies targeting transcription factors
title_fullStr	How cancer cells remodel lipid metabolism: strategies targeting transcription factors
title_full_unstemmed	How cancer cells remodel lipid metabolism: strategies targeting transcription factors
title_sort	how cancer cells remodel lipid metabolism: strategies targeting transcription factors
publisher	BMC
publishDate	2021
url	https://doaj.org/article/455c5ff4664c4db8b9869f297a4946e8
work_keys_str_mv	AT dowonjeong howcancercellsremodellipidmetabolismstrategiestargetingtranscriptionfactors AT seulbeelee howcancercellsremodellipidmetabolismstrategiestargetingtranscriptionfactors AT yangsookchun howcancercellsremodellipidmetabolismstrategiestargetingtranscriptionfactors
_version_	1718429102863548416

How cancer cells remodel lipid metabolism: strategies targeting transcription factors

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