Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders

Abstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation...

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Autores principales: Ji Sun Kim, Sungkean Kim, Ho-Sung Lee, Young Joon Kwon, Hwa Young Lee, Se-Hoon Shim
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/455d8457f8074bc091aaa5c071b4ff3d
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spelling oai:doaj.org-article:455d8457f8074bc091aaa5c071b4ff3d2021-12-02T13:27:04ZAuditory evoked potentials and suicidal behaviors in patients with major depressive disorders10.1038/s41598-021-86602-72045-2322https://doaj.org/article/455d8457f8074bc091aaa5c071b4ff3d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86602-7https://doaj.org/toc/2045-2322Abstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation (SI). It included 130 participants (45 depressed patients with SA, 49 depressed patients with SI, and 36 healthy controls) aged > 18 years who exhibited LDAEP during electroencephalography. Psychological characteristics and event-related potentials of the three groups were compared. There was no significant difference in LDAEP between major depressive disorder (MDD) patients with SA and SI (p = 0.59). MDD patients with SI, who attempted suicide had significantly lower LDAEP than healthy controls (p = 0.01 and p = 0.01, respectively). However, the significance disappeared when psychological characteristics were controlled. Our results suggest that LDAEP might not be possible biomarkers for suicidal behaviors in patients with MDD. Further studies to assess the biological basis of suicide and identify the underlying dimensions that mediate the relationship between the biological basis and suicidal behaviors will be needed.Ji Sun KimSungkean KimHo-Sung LeeYoung Joon KwonHwa Young LeeSe-Hoon ShimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ji Sun Kim
Sungkean Kim
Ho-Sung Lee
Young Joon Kwon
Hwa Young Lee
Se-Hoon Shim
Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
description Abstract Loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a biological marker of central serotonergic activity related to suicides. This study’s objective was to analyze the difference in LDAEP between depressed patients with suicide attempts (SA) and suicidal ideation (SI). It included 130 participants (45 depressed patients with SA, 49 depressed patients with SI, and 36 healthy controls) aged > 18 years who exhibited LDAEP during electroencephalography. Psychological characteristics and event-related potentials of the three groups were compared. There was no significant difference in LDAEP between major depressive disorder (MDD) patients with SA and SI (p = 0.59). MDD patients with SI, who attempted suicide had significantly lower LDAEP than healthy controls (p = 0.01 and p = 0.01, respectively). However, the significance disappeared when psychological characteristics were controlled. Our results suggest that LDAEP might not be possible biomarkers for suicidal behaviors in patients with MDD. Further studies to assess the biological basis of suicide and identify the underlying dimensions that mediate the relationship between the biological basis and suicidal behaviors will be needed.
format article
author Ji Sun Kim
Sungkean Kim
Ho-Sung Lee
Young Joon Kwon
Hwa Young Lee
Se-Hoon Shim
author_facet Ji Sun Kim
Sungkean Kim
Ho-Sung Lee
Young Joon Kwon
Hwa Young Lee
Se-Hoon Shim
author_sort Ji Sun Kim
title Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
title_short Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
title_full Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
title_fullStr Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
title_full_unstemmed Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
title_sort auditory evoked potentials and suicidal behaviors in patients with major depressive disorders
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/455d8457f8074bc091aaa5c071b4ff3d
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