Exposure to air pollution and renal function

Abstract Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. The adverse effects of air pollution can be observed in respiratory, circulatory systems but also in renal function. We decide to investigate the hypothesis indicating that we can observ...

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Autores principales:	Łukasz Kuźma, Jolanta Małyszko, Hanna Bachórzewska-Gajewska, Paweł Kralisz, Sławomir Dobrzycki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/455e06889fca4331a8666b986ca49496
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spelling	oai:doaj.org-article:455e06889fca4331a8666b986ca494962021-12-02T15:02:48ZExposure to air pollution and renal function10.1038/s41598-021-91000-02045-2322https://doaj.org/article/455e06889fca4331a8666b986ca494962021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91000-0https://doaj.org/toc/2045-2322Abstract Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. The adverse effects of air pollution can be observed in respiratory, circulatory systems but also in renal function. We decide to investigate the hypothesis indicating that we can observe not only long- but also short-term impact of air pollution on kidney function. We used linear, log-linear, and logistic regression models to assess the association between renal function and NO2, SO2, and PMs. Results are reported as beta (β) coefficients and odds ratios (OR) for an increase in interquartile range (IQR) concentration. 3554 patients (median age 66, men 53.2%) were included into final analysis. Chronic kidney disease (CKD) was diagnosed in 21.5%. The odds of CKD increased with increase in annual concentration of PM2.5 (OR for IQR increase = 1.07; 95% CI 1.01–1.15, P = 0.037) and NO2 (OR for IQR increase = 1.05; 95% CI 1.01–1.10, P = 0.047). The IQR increase in weekly PM2.5 concentration was associated with 2% reduction in expected eGFR (β = 0.02, 95% CI − 0.03; − 0.01). Medium- and short-term exposure to elevated air pollution levels was associated with a decrease in eGFR and development CKD. The main pollutants affecting the kidneys were PM2.5 and NO2.Łukasz KuźmaJolanta MałyszkoHanna Bachórzewska-GajewskaPaweł KraliszSławomir DobrzyckiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Łukasz Kuźma Jolanta Małyszko Hanna Bachórzewska-Gajewska Paweł Kralisz Sławomir Dobrzycki Exposure to air pollution and renal function
description	Abstract Air pollution contributes to the premature death of approximately 428,000 citizens of Europe every year. The adverse effects of air pollution can be observed in respiratory, circulatory systems but also in renal function. We decide to investigate the hypothesis indicating that we can observe not only long- but also short-term impact of air pollution on kidney function. We used linear, log-linear, and logistic regression models to assess the association between renal function and NO2, SO2, and PMs. Results are reported as beta (β) coefficients and odds ratios (OR) for an increase in interquartile range (IQR) concentration. 3554 patients (median age 66, men 53.2%) were included into final analysis. Chronic kidney disease (CKD) was diagnosed in 21.5%. The odds of CKD increased with increase in annual concentration of PM2.5 (OR for IQR increase = 1.07; 95% CI 1.01–1.15, P = 0.037) and NO2 (OR for IQR increase = 1.05; 95% CI 1.01–1.10, P = 0.047). The IQR increase in weekly PM2.5 concentration was associated with 2% reduction in expected eGFR (β = 0.02, 95% CI − 0.03; − 0.01). Medium- and short-term exposure to elevated air pollution levels was associated with a decrease in eGFR and development CKD. The main pollutants affecting the kidneys were PM2.5 and NO2.
format	article
author	Łukasz Kuźma Jolanta Małyszko Hanna Bachórzewska-Gajewska Paweł Kralisz Sławomir Dobrzycki
author_facet	Łukasz Kuźma Jolanta Małyszko Hanna Bachórzewska-Gajewska Paweł Kralisz Sławomir Dobrzycki
author_sort	Łukasz Kuźma
title	Exposure to air pollution and renal function
title_short	Exposure to air pollution and renal function
title_full	Exposure to air pollution and renal function
title_fullStr	Exposure to air pollution and renal function
title_full_unstemmed	Exposure to air pollution and renal function
title_sort	exposure to air pollution and renal function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/455e06889fca4331a8666b986ca49496
work_keys_str_mv	AT łukaszkuzma exposuretoairpollutionandrenalfunction AT jolantamałyszko exposuretoairpollutionandrenalfunction AT hannabachorzewskagajewska exposuretoairpollutionandrenalfunction AT pawełkralisz exposuretoairpollutionandrenalfunction AT sławomirdobrzycki exposuretoairpollutionandrenalfunction
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Exposure to air pollution and renal function

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