Genetic Analysis for Coronary Artery Disease Toward Diverse Populations

Coronary artery disease is one of the leading causes of death in the world, and as such, it is one of the diseases for which genetic analyses have been actively conducted. In the early days, analyses of families with the aggregation of early-onset myocardial infarction, such as those with familial h...

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Autores principales:	Kazuo Miyazawa, Kaoru Ito
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	coronary artery disease genome-wide association study population diversity biobank precision medicine Genetics QH426-470
Acceso en línea:	https://doaj.org/article/455ed182162a412a9f64b0d649570d7b
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spelling	oai:doaj.org-article:455ed182162a412a9f64b0d649570d7b2021-11-22T07:04:47ZGenetic Analysis for Coronary Artery Disease Toward Diverse Populations1664-802110.3389/fgene.2021.766485https://doaj.org/article/455ed182162a412a9f64b0d649570d7b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.766485/fullhttps://doaj.org/toc/1664-8021Coronary artery disease is one of the leading causes of death in the world, and as such, it is one of the diseases for which genetic analyses have been actively conducted. In the early days, analyses of families with the aggregation of early-onset myocardial infarction, such as those with familial hypercholesterolemia, was the main focus, but since the practical application of genome-wide association study, the analysis of coronary artery disease as a common disease has progressed, and many disease-susceptibility loci have been identified. In addition, with the advancement of technologies, it has become possible to identify relatively rare genetic variants in a population-based analysis. These advances have not only revealed the detailed disease mechanisms but have also enabled the quantification of individual genetic risk and the development of new therapeutic agents. In this paper, some of those items, which are important to know in the current genetic analyses for coronary artery disease, are discussed.Kazuo MiyazawaKaoru ItoFrontiers Media S.A.articlecoronary artery diseasegenome-wide association studypopulation diversitybiobankprecision medicineGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary artery disease genome-wide association study population diversity biobank precision medicine Genetics QH426-470
spellingShingle	coronary artery disease genome-wide association study population diversity biobank precision medicine Genetics QH426-470 Kazuo Miyazawa Kaoru Ito Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
description	Coronary artery disease is one of the leading causes of death in the world, and as such, it is one of the diseases for which genetic analyses have been actively conducted. In the early days, analyses of families with the aggregation of early-onset myocardial infarction, such as those with familial hypercholesterolemia, was the main focus, but since the practical application of genome-wide association study, the analysis of coronary artery disease as a common disease has progressed, and many disease-susceptibility loci have been identified. In addition, with the advancement of technologies, it has become possible to identify relatively rare genetic variants in a population-based analysis. These advances have not only revealed the detailed disease mechanisms but have also enabled the quantification of individual genetic risk and the development of new therapeutic agents. In this paper, some of those items, which are important to know in the current genetic analyses for coronary artery disease, are discussed.
format	article
author	Kazuo Miyazawa Kaoru Ito
author_facet	Kazuo Miyazawa Kaoru Ito
author_sort	Kazuo Miyazawa
title	Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
title_short	Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
title_full	Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
title_fullStr	Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
title_full_unstemmed	Genetic Analysis for Coronary Artery Disease Toward Diverse Populations
title_sort	genetic analysis for coronary artery disease toward diverse populations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/455ed182162a412a9f64b0d649570d7b
work_keys_str_mv	AT kazuomiyazawa geneticanalysisforcoronaryarterydiseasetowarddiversepopulations AT kaoruito geneticanalysisforcoronaryarterydiseasetowarddiversepopulations
_version_	1718418098801868800

Genetic Analysis for Coronary Artery Disease Toward Diverse Populations

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