Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo

Marta Grodzik1, Ewa Sawosz1, Mateusz Wierzbicki1, Piotr Orlowski1, Anna Hotowy2, Tomasz Niemiec1, Maciej Szmidt3, Katarzyna Mitura4, Andr&eacute; Chwalibog21Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Basic Anima...

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Autores principales:	Grodzik M, Sawosz E, Wierzbicki M, Orlowski P, Hotowy A, Niemiec T, Szmidt M, Mitura K, Chwalibog A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/456039c56faf463b8f4bb753654bc604
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spelling	oai:doaj.org-article:456039c56faf463b8f4bb753654bc6042021-12-02T02:10:26ZNanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo1176-91141178-2013https://doaj.org/article/456039c56faf463b8f4bb753654bc6042011-11-01T00:00:00Zhttp://www.dovepress.com/nanoparticles-of-carbon-allotropes-inhibit-glioblastoma-multiforme-ang-a8740https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Marta Grodzik1, Ewa Sawosz1, Mateusz Wierzbicki1, Piotr Orlowski1, Anna Hotowy2, Tomasz Niemiec1, Maciej Szmidt3, Katarzyna Mitura4, Andr&eacute; Chwalibog21Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Basic Animal and Veterinary Science, University of Copenhagen, Copenhagen, Denmark; 3Division of Histology and Embryology, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Biomedical Engineering, Koszalin University of Technology, Koszalin, PolandAbstract: The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chorioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, and vessel area. Quantitative real-time polymerase chain reaction analysis showed downregulated fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.Keywords: cancer, nanoparticle, embryo, angiogenesis, FGF-2, VEGFGrodzik MSawosz EWierzbicki MOrlowski PHotowy ANiemiec TSzmidt MMitura KChwalibog ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 3041-3048 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Grodzik M Sawosz E Wierzbicki M Orlowski P Hotowy A Niemiec T Szmidt M Mitura K Chwalibog A Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
description	Marta Grodzik1, Ewa Sawosz1, Mateusz Wierzbicki1, Piotr Orlowski1, Anna Hotowy2, Tomasz Niemiec1, Maciej Szmidt3, Katarzyna Mitura4, Andr&eacute; Chwalibog21Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Basic Animal and Veterinary Science, University of Copenhagen, Copenhagen, Denmark; 3Division of Histology and Embryology, Warsaw University of Life Sciences, Warsaw, Poland; 4Department of Biomedical Engineering, Koszalin University of Technology, Koszalin, PolandAbstract: The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chorioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, and vessel area. Quantitative real-time polymerase chain reaction analysis showed downregulated fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.Keywords: cancer, nanoparticle, embryo, angiogenesis, FGF-2, VEGF
format	article
author	Grodzik M Sawosz E Wierzbicki M Orlowski P Hotowy A Niemiec T Szmidt M Mitura K Chwalibog A
author_facet	Grodzik M Sawosz E Wierzbicki M Orlowski P Hotowy A Niemiec T Szmidt M Mitura K Chwalibog A
author_sort	Grodzik M
title	Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
title_short	Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
title_full	Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
title_fullStr	Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
title_full_unstemmed	Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
title_sort	nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/456039c56faf463b8f4bb753654bc604
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Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo

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