Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant

LncRNA SNHG7 shows a strong relationship with malignant behavior of cancer cells and poor clinical outcome in cancer. The resistance of ovarian cancer for Paclitaxel seriously limits the clinical efficacy in chemotherapy for ovarian cancer patients. In this study, we investigated whether lncRNA SNHG...

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Autores principales:	Jin Zhang, Rui Zhang, Yongju Ye
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	lncrna snhg7 eif4g2 paclitaxel resistance ovarian cancer Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/45635bb5a73644c4b69148b84eb61c35
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spelling	oai:doaj.org-article:45635bb5a73644c4b69148b84eb61c352021-11-04T15:51:55ZLong non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant2165-59792165-598710.1080/21655979.2021.1999555https://doaj.org/article/45635bb5a73644c4b69148b84eb61c352021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1999555https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987LncRNA SNHG7 shows a strong relationship with malignant behavior of cancer cells and poor clinical outcome in cancer. The resistance of ovarian cancer for Paclitaxel seriously limits the clinical efficacy in chemotherapy for ovarian cancer patients. In this study, we investigated whether lncRNA SNHG7 was involved in Paclitaxel sensitivity of ovarian cancer as well as the underlying mechanism regulating the behavior of ovarian cancer cells with Paclitaxel resistance. The experiment results of wound healing and transwell showed that in paclitaxel-resistant ovarian cancer cells, transfection with siRNA-SNHG7 in ovarian cancer cells reduced cell migration and invasion. And cell cycle was observed by means of Flow cytometry. RNA immunoprecipitation assay was performed to analyze the interaction of lncRNA SNHG7 and EIF4G2. Overexpression of EIF4G2 by transfection with Ov- EIF4G2 plasmids efficiently blocked the changes of migration and invasion, as well as G0/1 arrest caused by lncRNA SNHG7 silencing. Taken together, these results demonstrated that lncRNA SNHG7 could affect the degradation of EIF4G2 to regulate the sensitivity of ovarian cancer to Paclitaxel, inhibit cell viability, migration and invasion. The interaction of lncRNA SNHG7 and EIF4G2 plays an important role in the migrative and invasive activity and Paclitaxel -resistance of ovarian cancer cells.Jin ZhangRui ZhangYongju YeTaylor & Francis Grouparticlelncrna snhg7eif4g2paclitaxel resistanceovarian cancerBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncrna snhg7 eif4g2 paclitaxel resistance ovarian cancer Biotechnology TP248.13-248.65
spellingShingle	lncrna snhg7 eif4g2 paclitaxel resistance ovarian cancer Biotechnology TP248.13-248.65 Jin Zhang Rui Zhang Yongju Ye Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
description	LncRNA SNHG7 shows a strong relationship with malignant behavior of cancer cells and poor clinical outcome in cancer. The resistance of ovarian cancer for Paclitaxel seriously limits the clinical efficacy in chemotherapy for ovarian cancer patients. In this study, we investigated whether lncRNA SNHG7 was involved in Paclitaxel sensitivity of ovarian cancer as well as the underlying mechanism regulating the behavior of ovarian cancer cells with Paclitaxel resistance. The experiment results of wound healing and transwell showed that in paclitaxel-resistant ovarian cancer cells, transfection with siRNA-SNHG7 in ovarian cancer cells reduced cell migration and invasion. And cell cycle was observed by means of Flow cytometry. RNA immunoprecipitation assay was performed to analyze the interaction of lncRNA SNHG7 and EIF4G2. Overexpression of EIF4G2 by transfection with Ov- EIF4G2 plasmids efficiently blocked the changes of migration and invasion, as well as G0/1 arrest caused by lncRNA SNHG7 silencing. Taken together, these results demonstrated that lncRNA SNHG7 could affect the degradation of EIF4G2 to regulate the sensitivity of ovarian cancer to Paclitaxel, inhibit cell viability, migration and invasion. The interaction of lncRNA SNHG7 and EIF4G2 plays an important role in the migrative and invasive activity and Paclitaxel -resistance of ovarian cancer cells.
format	article
author	Jin Zhang Rui Zhang Yongju Ye
author_facet	Jin Zhang Rui Zhang Yongju Ye
author_sort	Jin Zhang
title	Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
title_short	Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
title_full	Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
title_fullStr	Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
title_full_unstemmed	Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
title_sort	long non-coding rna (lncrna) snhg7/ eukaryotic translation initiation factor 4 gamma 2 (eif4g2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/45635bb5a73644c4b69148b84eb61c35
work_keys_str_mv	AT jinzhang longnoncodingrnalncrnasnhg7eukaryotictranslationinitiationfactor4gamma2eif4g2involvesinthemalignanteventsofovariancancercellswithpaclitaxelresistant AT ruizhang longnoncodingrnalncrnasnhg7eukaryotictranslationinitiationfactor4gamma2eif4g2involvesinthemalignanteventsofovariancancercellswithpaclitaxelresistant AT yongjuye longnoncodingrnalncrnasnhg7eukaryotictranslationinitiationfactor4gamma2eif4g2involvesinthemalignanteventsofovariancancercellswithpaclitaxelresistant
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Long non-coding RNA (LncRNA) SNHG7/ Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) involves in the malignant events of ovarian cancer cells with paclitaxel resistant

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