Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves

Background. In view of the worsening forecast for global temperature rise worldwide, it seems relevant to study the effects of abnormal heat waves on systemic regulatory processes in people with chronic diseases, in particular coronary artery disease (CAD).Aims. This study aimed to investigate the e...

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Autores principales:	A. K. Tikhaze, G. G. Konovalova, M. K. Osyaeva, M. D. Smirnova, T. V. Martynyuk, V. Z. Lankin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	oxidative stress malonic dialdehyde cu zn-containing superoxide dismutase hyperthermia atherosclerosis coronary artery disease Science Q
Acceso en línea:	https://doaj.org/article/4563eb553a214b888f21e77da02ce77d
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spelling	oai:doaj.org-article:4563eb553a214b888f21e77da02ce77d2021-11-23T06:14:46ZRegulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves2541-94202587-959610.29413/ABS.2021-6.5.3https://doaj.org/article/4563eb553a214b888f21e77da02ce77d2021-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/3026https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. In view of the worsening forecast for global temperature rise worldwide, it seems relevant to study the effects of abnormal heat waves on systemic regulatory processes in people with chronic diseases, in particular coronary artery disease (CAD).Aims. This study aimed to investigate the effect of hyperthermia on oxidative stress parameters in patients with various severity of CAD and in healthy subjects.Materials and methods. We studied the level of malonic dialdehyde (MDA) and the activity of Cu,Zn-containing superoxide dismutase (Cu,Zn-SOD) in healthy subjects under conditions of 30-day long simulated hyperthermia and in patients with different severity of CAD after the summer heat wavesResults. We revealed signs of oxidative stress in healthy volunteers during model hyperthermia that manifested as an increase in content of MDA in blood plasma. At the same time we observed increasing activity of Cu,Zn-SOD in erythrocytes that utilizes reactive oxygen species. The increase of Cu,Zn-SOD activity started with a certain latency what also can be explained by de novo enzyme biosynthesis induction. We also studied oxidative stress parameters in patients at high and moderate cardiovascular risk according to the SCORE risk chart with uncomplicated CAD course and in patients with complicated CAD with severe coronary damage according to angiography during the summer heat waves. We observed accumulation of MDA in blood plasma and increasing activity of erythrocyte Cu,Zn-SOD in patients with uncomplicated CAD. At the same time we noted that accumulation of MDA in blood plasma was not followed by any increase in activity of red blood cell Cu,Zn-SOD in patients with severe complicated CAD. This fact indicates dysregulation of free radical processes in patients with severe course of CAD during the heat waves.Conclusions. The dysregulation of free-radical processes in patients with a severe clinical course of CAD has been revealed.A. K. TikhazeG. G. KonovalovaM. K. OsyaevaM. D. SmirnovaT. V. MartynyukV. Z. LankinScientific Сentre for Family Health and Human Reproduction Problemsarticleoxidative stressmalonic dialdehydecuzn-containing superoxide dismutasehyperthermiaatherosclerosiscoronary artery diseaseScienceQRUActa Biomedica Scientifica, Vol 6, Iss 5, Pp 19-29 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	oxidative stress malonic dialdehyde cu zn-containing superoxide dismutase hyperthermia atherosclerosis coronary artery disease Science Q
spellingShingle	oxidative stress malonic dialdehyde cu zn-containing superoxide dismutase hyperthermia atherosclerosis coronary artery disease Science Q A. K. Tikhaze G. G. Konovalova M. K. Osyaeva M. D. Smirnova T. V. Martynyuk V. Z. Lankin Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
description	Background. In view of the worsening forecast for global temperature rise worldwide, it seems relevant to study the effects of abnormal heat waves on systemic regulatory processes in people with chronic diseases, in particular coronary artery disease (CAD).Aims. This study aimed to investigate the effect of hyperthermia on oxidative stress parameters in patients with various severity of CAD and in healthy subjects.Materials and methods. We studied the level of malonic dialdehyde (MDA) and the activity of Cu,Zn-containing superoxide dismutase (Cu,Zn-SOD) in healthy subjects under conditions of 30-day long simulated hyperthermia and in patients with different severity of CAD after the summer heat wavesResults. We revealed signs of oxidative stress in healthy volunteers during model hyperthermia that manifested as an increase in content of MDA in blood plasma. At the same time we observed increasing activity of Cu,Zn-SOD in erythrocytes that utilizes reactive oxygen species. The increase of Cu,Zn-SOD activity started with a certain latency what also can be explained by de novo enzyme biosynthesis induction. We also studied oxidative stress parameters in patients at high and moderate cardiovascular risk according to the SCORE risk chart with uncomplicated CAD course and in patients with complicated CAD with severe coronary damage according to angiography during the summer heat waves. We observed accumulation of MDA in blood plasma and increasing activity of erythrocyte Cu,Zn-SOD in patients with uncomplicated CAD. At the same time we noted that accumulation of MDA in blood plasma was not followed by any increase in activity of red blood cell Cu,Zn-SOD in patients with severe complicated CAD. This fact indicates dysregulation of free radical processes in patients with severe course of CAD during the heat waves.Conclusions. The dysregulation of free-radical processes in patients with a severe clinical course of CAD has been revealed.
format	article
author	A. K. Tikhaze G. G. Konovalova M. K. Osyaeva M. D. Smirnova T. V. Martynyuk V. Z. Lankin
author_facet	A. K. Tikhaze G. G. Konovalova M. K. Osyaeva M. D. Smirnova T. V. Martynyuk V. Z. Lankin
author_sort	A. K. Tikhaze
title	Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
title_short	Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
title_full	Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
title_fullStr	Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
title_full_unstemmed	Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
title_sort	regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/4563eb553a214b888f21e77da02ce77d
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Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves

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