Venous thromboembolism in patients hospitalized for knee joint replacement surgery

Abstract Patients undergoing knee joint replacement (KJR) are at high risk of postoperative venous thromboembolism (VTE), but data on the time trends of VTE rate in this population are sparse. In this analysis of the German nationwide inpatient sample, we included all hospitalizations for elective p...

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Autores principales:	Karsten Keller, Lukas Hobohm, Stefano Barco, Irene Schmidtmann, Thomas Münzel, Martin Engelhardt, Lukas Eckhard, Stavros V. Konstantinides, Philipp Drees
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45643a6260674d1fbe7ee212fff36317
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spelling	oai:doaj.org-article:45643a6260674d1fbe7ee212fff363172021-12-02T14:01:28ZVenous thromboembolism in patients hospitalized for knee joint replacement surgery10.1038/s41598-020-79490-w2045-2322https://doaj.org/article/45643a6260674d1fbe7ee212fff363172020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79490-whttps://doaj.org/toc/2045-2322Abstract Patients undergoing knee joint replacement (KJR) are at high risk of postoperative venous thromboembolism (VTE), but data on the time trends of VTE rate in this population are sparse. In this analysis of the German nationwide inpatient sample, we included all hospitalizations for elective primary KJR in Germany 2005–2016. Overall, 1,804,496 hospitalized patients with elective primary KJR (65.1% women, 70.0 years [IQR 63.0–76.0]) were included in the analysis. During hospitalization, VTE was documented in 23,297 (1.3%) patients. Total numbers of primary KJR increased from 129,832 in 2005 to 167,881 in 2016 (β-(slope)-estimate 1,978 [95% CI 1,951 to 2,004], P < 0.001). In-hospital VTE decreased from 2,429 (1.9% of all hospitalizations for KJR) to 1,548 (0.9%) cases (β-estimate − 0.77 [95% CI − 0.81 to − 0.72], P < 0.001), and in-hospital death rate from 0.14% (184 deaths) to 0.09% (146 deaths) (β-estimate − 0.44 deaths per year [95% CI − 0.59 to − 0.30], P < 0.001). Infections during hospitalization were associated with a higher VTE risk. VTE events were independently associated with in-hospital death (OR 20.86 [95% CI 18.78–23.15], P < 0.001). Annual number of KJR performed in Germany increased by almost 30% between 2005 and 2016. In parallel, in-hospital VTE rates decreased from 1.9 to 0.9%. Perioperative infections were associated with higher risk for VTE. Patients who developed VTE had a 21-fold increased risk of in-hospital death.Karsten KellerLukas HobohmStefano BarcoIrene SchmidtmannThomas MünzelMartin EngelhardtLukas EckhardStavros V. KonstantinidesPhilipp DreesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karsten Keller Lukas Hobohm Stefano Barco Irene Schmidtmann Thomas Münzel Martin Engelhardt Lukas Eckhard Stavros V. Konstantinides Philipp Drees Venous thromboembolism in patients hospitalized for knee joint replacement surgery
description	Abstract Patients undergoing knee joint replacement (KJR) are at high risk of postoperative venous thromboembolism (VTE), but data on the time trends of VTE rate in this population are sparse. In this analysis of the German nationwide inpatient sample, we included all hospitalizations for elective primary KJR in Germany 2005–2016. Overall, 1,804,496 hospitalized patients with elective primary KJR (65.1% women, 70.0 years [IQR 63.0–76.0]) were included in the analysis. During hospitalization, VTE was documented in 23,297 (1.3%) patients. Total numbers of primary KJR increased from 129,832 in 2005 to 167,881 in 2016 (β-(slope)-estimate 1,978 [95% CI 1,951 to 2,004], P < 0.001). In-hospital VTE decreased from 2,429 (1.9% of all hospitalizations for KJR) to 1,548 (0.9%) cases (β-estimate − 0.77 [95% CI − 0.81 to − 0.72], P < 0.001), and in-hospital death rate from 0.14% (184 deaths) to 0.09% (146 deaths) (β-estimate − 0.44 deaths per year [95% CI − 0.59 to − 0.30], P < 0.001). Infections during hospitalization were associated with a higher VTE risk. VTE events were independently associated with in-hospital death (OR 20.86 [95% CI 18.78–23.15], P < 0.001). Annual number of KJR performed in Germany increased by almost 30% between 2005 and 2016. In parallel, in-hospital VTE rates decreased from 1.9 to 0.9%. Perioperative infections were associated with higher risk for VTE. Patients who developed VTE had a 21-fold increased risk of in-hospital death.
format	article
author	Karsten Keller Lukas Hobohm Stefano Barco Irene Schmidtmann Thomas Münzel Martin Engelhardt Lukas Eckhard Stavros V. Konstantinides Philipp Drees
author_facet	Karsten Keller Lukas Hobohm Stefano Barco Irene Schmidtmann Thomas Münzel Martin Engelhardt Lukas Eckhard Stavros V. Konstantinides Philipp Drees
author_sort	Karsten Keller
title	Venous thromboembolism in patients hospitalized for knee joint replacement surgery
title_short	Venous thromboembolism in patients hospitalized for knee joint replacement surgery
title_full	Venous thromboembolism in patients hospitalized for knee joint replacement surgery
title_fullStr	Venous thromboembolism in patients hospitalized for knee joint replacement surgery
title_full_unstemmed	Venous thromboembolism in patients hospitalized for knee joint replacement surgery
title_sort	venous thromboembolism in patients hospitalized for knee joint replacement surgery
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/45643a6260674d1fbe7ee212fff36317
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Venous thromboembolism in patients hospitalized for knee joint replacement surgery

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