The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Tyrosine kinase signalling in cancer cells promotes immune evasion. Here, the authors show that tyrosine kinases engage scaffold protein Shc1 to promote immunosuppression in breast cancer by simultaneously activating STAT3 immunosuppressive signals and impairing STAT1-driven anti-tumour immune respo...

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Autores principales:	Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt, Steven Hébert, Stephanie Totten, Nicolas De Jay, Maria Carolina Festa, Yoon Kow Young, Young Kyuen Im, Tony Pawson, Antonis E. Koromilas, William J. Muller, Koren K. Mann, Claudia L. Kleinman, Josie Ursini-Siegel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa
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spelling	oai:doaj.org-article:4564af3090224e7180bdbbc6e315baaa2021-12-02T14:40:34ZThe Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression10.1038/ncomms146382041-1723https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14638https://doaj.org/toc/2041-1723Tyrosine kinase signalling in cancer cells promotes immune evasion. Here, the authors show that tyrosine kinases engage scaffold protein Shc1 to promote immunosuppression in breast cancer by simultaneously activating STAT3 immunosuppressive signals and impairing STAT1-driven anti-tumour immune responses.Ryuhjin AhnValérie SabourinAlicia M. BoltSteven HébertStephanie TottenNicolas De JayMaria Carolina FestaYoon Kow YoungYoung Kyuen ImTony PawsonAntonis E. KoromilasWilliam J. MullerKoren K. MannClaudia L. KleinmanJosie Ursini-SiegelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryuhjin Ahn Valérie Sabourin Alicia M. Bolt Steven Hébert Stephanie Totten Nicolas De Jay Maria Carolina Festa Yoon Kow Young Young Kyuen Im Tony Pawson Antonis E. Koromilas William J. Muller Koren K. Mann Claudia L. Kleinman Josie Ursini-Siegel The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
description	Tyrosine kinase signalling in cancer cells promotes immune evasion. Here, the authors show that tyrosine kinases engage scaffold protein Shc1 to promote immunosuppression in breast cancer by simultaneously activating STAT3 immunosuppressive signals and impairing STAT1-driven anti-tumour immune responses.
format	article
author	Ryuhjin Ahn Valérie Sabourin Alicia M. Bolt Steven Hébert Stephanie Totten Nicolas De Jay Maria Carolina Festa Yoon Kow Young Young Kyuen Im Tony Pawson Antonis E. Koromilas William J. Muller Koren K. Mann Claudia L. Kleinman Josie Ursini-Siegel
author_facet	Ryuhjin Ahn Valérie Sabourin Alicia M. Bolt Steven Hébert Stephanie Totten Nicolas De Jay Maria Carolina Festa Yoon Kow Young Young Kyuen Im Tony Pawson Antonis E. Koromilas William J. Muller Koren K. Mann Claudia L. Kleinman Josie Ursini-Siegel
author_sort	Ryuhjin Ahn
title	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
title_short	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
title_full	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
title_fullStr	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
title_full_unstemmed	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
title_sort	shc1 adaptor simultaneously balances stat1 and stat3 activity to promote breast cancer immune suppression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa
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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

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