Associations between the thyroid panel and serum protein concentrations across pregnancy

Abstract Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in the...

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Autores principales:	Barbara Lisowska-Myjak, Agnieszka Strawa, Hanna Zborowska, Artur Jakimiuk, Ewa Skarżyńska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45675670376b43f0a419231b5e83c913
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spelling	oai:doaj.org-article:45675670376b43f0a419231b5e83c9132021-12-02T16:35:28ZAssociations between the thyroid panel and serum protein concentrations across pregnancy10.1038/s41598-021-94358-32045-2322https://doaj.org/article/45675670376b43f0a419231b5e83c9132021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94358-3https://doaj.org/toc/2045-2322Abstract Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in their clinical assessment. Concentrations of thyroid stimulating hormone (TSH), free tri-iodothyronine (fT3) and free thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha2-, beta-1-, beta-2- and gamma-globulins), representative proteins—albumin (ALB), transferrin (TRF), alpha-2-macroglobulin (AMG) and ceruloplasmin (CER) were measured in 136 serum samples from 65 women in their consecutive trimesters of pregnancy. The concentrations of TSH, fT4 and fT3 were significantly correlated (p < 0.05) with the concentrations of the albumin, alpha-2- and beta-1 globulin fractions. Significant correlations (p < 0.05) which were positive between fT4 and ALB and negative between fT4 and TRF were established throughout pregnancy. Significant negative correlations (p < 0.05) were demonstrated for fT3 with alpha-2-globulin, AMG and CER. Changes in the serum concentrations of thyroid hormones seen between the trimesters were found to correlate with the concentrations of high-abundance serum proteins. Opposite directions of correlations between fT4 and ALB and fT4 and TRF observed throughout pregnancy may indicate the shared biological role of these parameters in maintaining maternal homeostasis and they suggest their potential use in the clinic as a simple biomarker panel. A negative correlation of fT3 with CER in the second trimester possibly reflects their involvement in the active regulation of metabolic processes.Barbara Lisowska-MyjakAgnieszka StrawaHanna ZborowskaArtur JakimiukEwa SkarżyńskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbara Lisowska-Myjak Agnieszka Strawa Hanna Zborowska Artur Jakimiuk Ewa Skarżyńska Associations between the thyroid panel and serum protein concentrations across pregnancy
description	Abstract Establishing any characteristic associations between the serum parameters of thyroid function and serum proteins in pregnancy may aid in elucidating the role of the thyroid gland in the regulation of pregnancy-specific metabolic processes and in selecting candidate biomarkers for use in their clinical assessment. Concentrations of thyroid stimulating hormone (TSH), free tri-iodothyronine (fT3) and free thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha2-, beta-1-, beta-2- and gamma-globulins), representative proteins—albumin (ALB), transferrin (TRF), alpha-2-macroglobulin (AMG) and ceruloplasmin (CER) were measured in 136 serum samples from 65 women in their consecutive trimesters of pregnancy. The concentrations of TSH, fT4 and fT3 were significantly correlated (p < 0.05) with the concentrations of the albumin, alpha-2- and beta-1 globulin fractions. Significant correlations (p < 0.05) which were positive between fT4 and ALB and negative between fT4 and TRF were established throughout pregnancy. Significant negative correlations (p < 0.05) were demonstrated for fT3 with alpha-2-globulin, AMG and CER. Changes in the serum concentrations of thyroid hormones seen between the trimesters were found to correlate with the concentrations of high-abundance serum proteins. Opposite directions of correlations between fT4 and ALB and fT4 and TRF observed throughout pregnancy may indicate the shared biological role of these parameters in maintaining maternal homeostasis and they suggest their potential use in the clinic as a simple biomarker panel. A negative correlation of fT3 with CER in the second trimester possibly reflects their involvement in the active regulation of metabolic processes.
format	article
author	Barbara Lisowska-Myjak Agnieszka Strawa Hanna Zborowska Artur Jakimiuk Ewa Skarżyńska
author_facet	Barbara Lisowska-Myjak Agnieszka Strawa Hanna Zborowska Artur Jakimiuk Ewa Skarżyńska
author_sort	Barbara Lisowska-Myjak
title	Associations between the thyroid panel and serum protein concentrations across pregnancy
title_short	Associations between the thyroid panel and serum protein concentrations across pregnancy
title_full	Associations between the thyroid panel and serum protein concentrations across pregnancy
title_fullStr	Associations between the thyroid panel and serum protein concentrations across pregnancy
title_full_unstemmed	Associations between the thyroid panel and serum protein concentrations across pregnancy
title_sort	associations between the thyroid panel and serum protein concentrations across pregnancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/45675670376b43f0a419231b5e83c913
work_keys_str_mv	AT barbaralisowskamyjak associationsbetweenthethyroidpanelandserumproteinconcentrationsacrosspregnancy AT agnieszkastrawa associationsbetweenthethyroidpanelandserumproteinconcentrationsacrosspregnancy AT hannazborowska associationsbetweenthethyroidpanelandserumproteinconcentrationsacrosspregnancy AT arturjakimiuk associationsbetweenthethyroidpanelandserumproteinconcentrationsacrosspregnancy AT ewaskarzynska associationsbetweenthethyroidpanelandserumproteinconcentrationsacrosspregnancy
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Associations between the thyroid panel and serum protein concentrations across pregnancy

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