The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study

Abstract Ménière disease (MD) is an idiopathic inner ear disorder, and endolymphatic hydrops (EH) being considered to be its pathological basis. Currently, there is no gold standard for diagnosing MD. Previous study has reported visualized EH using MRI by intratympanic gadolinium-based contrast medi...

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Autores principales:	Wen Xie, Ting Shu, Jiali Liu, Haisen Peng, Niki Karpeta, Pedro Marques, Yuehui Liu, Maoli Duan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4569834756354222a2e2239de4924d4e
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spelling	oai:doaj.org-article:4569834756354222a2e2239de4924d4e2021-12-02T13:26:24ZThe relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study10.1038/s41598-021-86589-12045-2322https://doaj.org/article/4569834756354222a2e2239de4924d4e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86589-1https://doaj.org/toc/2045-2322Abstract Ménière disease (MD) is an idiopathic inner ear disorder, and endolymphatic hydrops (EH) being considered to be its pathological basis. Currently, there is no gold standard for diagnosing MD. Previous study has reported visualized EH using MRI by intratympanic gadolinium-based contrast media (GBCM) administration (IT-Gd) in patients with MD, and this technique was gradually established for MD diagnosis. However, few studies reported their diagnostic sensitivity and specificity in clinical application. This prospective study aimed at investigating the clinical characteristics and magnetic resonance imaging (MRI) results of patients with MD, and analyzing the relationship between clinical results and MRI findings in MD patients. Our study shows that the diagnostic sensitivity and specificity of MRI were 79.2% and 80.7% respectively. Moreover, there was no significant correlation between hearing levels and cochlear grading scores, nor vestibular grading scores. The duration of disease was not significantly associated with cochlear or vestibular grading scores. These findings suggest that IT-Gd MRI offers reliable radiological diagnostic criteria for MD.Wen XieTing ShuJiali LiuHaisen PengNiki KarpetaPedro MarquesYuehui LiuMaoli DuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen Xie Ting Shu Jiali Liu Haisen Peng Niki Karpeta Pedro Marques Yuehui Liu Maoli Duan The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
description	Abstract Ménière disease (MD) is an idiopathic inner ear disorder, and endolymphatic hydrops (EH) being considered to be its pathological basis. Currently, there is no gold standard for diagnosing MD. Previous study has reported visualized EH using MRI by intratympanic gadolinium-based contrast media (GBCM) administration (IT-Gd) in patients with MD, and this technique was gradually established for MD diagnosis. However, few studies reported their diagnostic sensitivity and specificity in clinical application. This prospective study aimed at investigating the clinical characteristics and magnetic resonance imaging (MRI) results of patients with MD, and analyzing the relationship between clinical results and MRI findings in MD patients. Our study shows that the diagnostic sensitivity and specificity of MRI were 79.2% and 80.7% respectively. Moreover, there was no significant correlation between hearing levels and cochlear grading scores, nor vestibular grading scores. The duration of disease was not significantly associated with cochlear or vestibular grading scores. These findings suggest that IT-Gd MRI offers reliable radiological diagnostic criteria for MD.
format	article
author	Wen Xie Ting Shu Jiali Liu Haisen Peng Niki Karpeta Pedro Marques Yuehui Liu Maoli Duan
author_facet	Wen Xie Ting Shu Jiali Liu Haisen Peng Niki Karpeta Pedro Marques Yuehui Liu Maoli Duan
author_sort	Wen Xie
title	The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
title_short	The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
title_full	The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
title_fullStr	The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
title_full_unstemmed	The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study
title_sort	relationship between clinical characteristics and magnetic resonance imaging results of ménière disease: a prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4569834756354222a2e2239de4924d4e
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The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study

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