Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Wenyi Gu,1,2 Chengtie Wu,3 Jiezhong Chen,1 Yin Xiao1 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia; 2Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia; 3State Key Laborato...

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Autores principales:	Gu W, Wu C, Chen J, Xiao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/456a8485ab994eb0975243bab2cc285d
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spelling	oai:doaj.org-article:456a8485ab994eb0975243bab2cc285d2021-12-02T03:18:32ZNanotechnology in the targeted drug delivery for bone diseases and bone regeneration1176-91141178-2013https://doaj.org/article/456a8485ab994eb0975243bab2cc285d2013-06-01T00:00:00Zhttp://www.dovepress.com/nanotechnology-in-the-targeted-drug-delivery-for-bone-diseases-and-bon-a13466https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wenyi Gu,1,2 Chengtie Wu,3 Jiezhong Chen,1 Yin Xiao1 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia; 2Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia; 3State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China Abstract: Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically. Keywords: nanoparticles, nanostructured scaffold, cancer bone metastasis, bone diseases, target drug delivery, bone regenerationGu WWu CChen JXiao YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2305-2317 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gu W Wu C Chen J Xiao Y Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
description	Wenyi Gu,1,2 Chengtie Wu,3 Jiezhong Chen,1 Yin Xiao1 1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia; 2Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia; 3State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China Abstract: Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically. Keywords: nanoparticles, nanostructured scaffold, cancer bone metastasis, bone diseases, target drug delivery, bone regeneration
format	article
author	Gu W Wu C Chen J Xiao Y
author_facet	Gu W Wu C Chen J Xiao Y
author_sort	Gu W
title	Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
title_short	Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
title_full	Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
title_fullStr	Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
title_full_unstemmed	Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
title_sort	nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/456a8485ab994eb0975243bab2cc285d
work_keys_str_mv	AT guw nanotechnologyinthetargeteddrugdeliveryforbonediseasesandboneregeneration AT wuc nanotechnologyinthetargeteddrugdeliveryforbonediseasesandboneregeneration AT chenj nanotechnologyinthetargeteddrugdeliveryforbonediseasesandboneregeneration AT xiaoy nanotechnologyinthetargeteddrugdeliveryforbonediseasesandboneregeneration
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Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

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