FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS

Abstract. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stre...

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Autores principales:	I. V. Shirolapov, V. F. Pyatin, O. V. Lavrov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune reactivity psycho-emotional examination stress neuroimmunoendocrine regulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/456a97e2850f401899290b15c0ea9e1d
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spelling	oai:doaj.org-article:456a97e2850f401899290b15c0ea9e1d2021-11-18T08:03:40ZFEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS1563-06252313-741X10.15789/1563-0625-2012-1-2-133-138https://doaj.org/article/456a97e2850f401899290b15c0ea9e1d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/312https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3+ T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3-CD16+CD56+ and CD3+CD16+CD56+), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19+ B cells, CD4+ T-helpers and CD8+ T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.I. V. ShirolapovV. F. PyatinO. V. LavrovSPb RAACIarticleimmune reactivitypsycho-emotional examination stressneuroimmunoendocrine regulationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 133-138 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune reactivity psycho-emotional examination stress neuroimmunoendocrine regulation Immunologic diseases. Allergy RC581-607
spellingShingle	immune reactivity psycho-emotional examination stress neuroimmunoendocrine regulation Immunologic diseases. Allergy RC581-607 I. V. Shirolapov V. F. Pyatin O. V. Lavrov FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
description	Abstract. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3+ T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3-CD16+CD56+ and CD3+CD16+CD56+), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19+ B cells, CD4+ T-helpers and CD8+ T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.
format	article
author	I. V. Shirolapov V. F. Pyatin O. V. Lavrov
author_facet	I. V. Shirolapov V. F. Pyatin O. V. Lavrov
author_sort	I. V. Shirolapov
title	FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
title_short	FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
title_full	FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
title_fullStr	FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
title_full_unstemmed	FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
title_sort	features of immune reactions in stress conditions associated associated with exams
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/456a97e2850f401899290b15c0ea9e1d
work_keys_str_mv	AT ivshirolapov featuresofimmunereactionsinstressconditionsassociatedassociatedwithexams AT vfpyatin featuresofimmunereactionsinstressconditionsassociatedassociatedwithexams AT ovlavrov featuresofimmunereactionsinstressconditionsassociatedassociatedwithexams
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FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS

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