Patterns of pituitary dysfunction three months or more after traumatic brain injury

Purpose: Chronic posttraumatic brain injury (TBI) pituitary dysfunction is not a newly discovered subject, it has been reported more frequently, probably due to increasing chances of exposure to its causes, mainly the road traffic accidents, sport-related injuries, falls, and injuries during wars. T...

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Autores principales:	Nassar Taha Yaseen, Fateh Al-Khaqani, Abbas Ali Mansour
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2018
Materias:	growth hormone deficiency head trauma hypopituitarism traumatic brain injury Medicine R
Acceso en línea:	https://doaj.org/article/456ad1a2f1654dfcb11538df7f5d316e
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spelling	oai:doaj.org-article:456ad1a2f1654dfcb11538df7f5d316e2021-12-02T18:50:07ZPatterns of pituitary dysfunction three months or more after traumatic brain injury2231-07702249-446410.4103/ajm.AJM_2_18https://doaj.org/article/456ad1a2f1654dfcb11538df7f5d316e2018-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_2_18https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Purpose: Chronic posttraumatic brain injury (TBI) pituitary dysfunction is not a newly discovered subject, it has been reported more frequently, probably due to increasing chances of exposure to its causes, mainly the road traffic accidents, sport-related injuries, falls, and injuries during wars. This study aims to estimate the frequency of pituitary dysfunction 3 months or more after head trauma and the patterns of hormonal deficiencies. Methods: A cross-sectional study was conducted between January 2016 and August 2017. Participants were patients having a history of moderate-to-severe TBI at least 3 months before enrolment. Pituitary function test was done for all patients to determine the frequency of pituitary dysfunction, the number of axes deficiencies, and which hormone is mostly affected. Statistical Package for the Social Sciences (SPSS) version 23.0 was used for univariate analysis, P < 0.05 was considered statistically significant. Results: Out of the 28 patients involved in this study, 17 (61%) had pituitary dysfunction, while 11 (39%) had not. Single hormonal defect was the most prevalent abnormality in 12 (43%), and the most affected hormone was the growth hormone (GH) in 14 patients (50%), followed by gonadal axis, thyroid stimulating hormone, and finally adrenocorticotropic hormone (ACTH), 6 (21%), 3 (11%), and 1 (4%), respectively. Conclusion: TBI pituitary dysfunction is more prevalent than was predicted in the population studied, single hormonal defect was found to be the most prevalent abnormality, being the GH is the most affected axis, and the ACTH seems to be the least.Nassar Taha YaseenFateh Al-KhaqaniAbbas Ali MansourThieme Medical and Scientific Publishers Pvt. Ltd.articlegrowth hormone deficiencyhead traumahypopituitarismtraumatic brain injuryMedicineRENAvicenna Journal of Medicine, Vol 8, Iss 04, Pp 125-132 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth hormone deficiency head trauma hypopituitarism traumatic brain injury Medicine R
spellingShingle	growth hormone deficiency head trauma hypopituitarism traumatic brain injury Medicine R Nassar Taha Yaseen Fateh Al-Khaqani Abbas Ali Mansour Patterns of pituitary dysfunction three months or more after traumatic brain injury
description	Purpose: Chronic posttraumatic brain injury (TBI) pituitary dysfunction is not a newly discovered subject, it has been reported more frequently, probably due to increasing chances of exposure to its causes, mainly the road traffic accidents, sport-related injuries, falls, and injuries during wars. This study aims to estimate the frequency of pituitary dysfunction 3 months or more after head trauma and the patterns of hormonal deficiencies. Methods: A cross-sectional study was conducted between January 2016 and August 2017. Participants were patients having a history of moderate-to-severe TBI at least 3 months before enrolment. Pituitary function test was done for all patients to determine the frequency of pituitary dysfunction, the number of axes deficiencies, and which hormone is mostly affected. Statistical Package for the Social Sciences (SPSS) version 23.0 was used for univariate analysis, P < 0.05 was considered statistically significant. Results: Out of the 28 patients involved in this study, 17 (61%) had pituitary dysfunction, while 11 (39%) had not. Single hormonal defect was the most prevalent abnormality in 12 (43%), and the most affected hormone was the growth hormone (GH) in 14 patients (50%), followed by gonadal axis, thyroid stimulating hormone, and finally adrenocorticotropic hormone (ACTH), 6 (21%), 3 (11%), and 1 (4%), respectively. Conclusion: TBI pituitary dysfunction is more prevalent than was predicted in the population studied, single hormonal defect was found to be the most prevalent abnormality, being the GH is the most affected axis, and the ACTH seems to be the least.
format	article
author	Nassar Taha Yaseen Fateh Al-Khaqani Abbas Ali Mansour
author_facet	Nassar Taha Yaseen Fateh Al-Khaqani Abbas Ali Mansour
author_sort	Nassar Taha Yaseen
title	Patterns of pituitary dysfunction three months or more after traumatic brain injury
title_short	Patterns of pituitary dysfunction three months or more after traumatic brain injury
title_full	Patterns of pituitary dysfunction three months or more after traumatic brain injury
title_fullStr	Patterns of pituitary dysfunction three months or more after traumatic brain injury
title_full_unstemmed	Patterns of pituitary dysfunction three months or more after traumatic brain injury
title_sort	patterns of pituitary dysfunction three months or more after traumatic brain injury
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2018
url	https://doaj.org/article/456ad1a2f1654dfcb11538df7f5d316e
work_keys_str_mv	AT nassartahayaseen patternsofpituitarydysfunctionthreemonthsormoreaftertraumaticbraininjury AT fatehalkhaqani patternsofpituitarydysfunctionthreemonthsormoreaftertraumaticbraininjury AT abbasalimansour patternsofpituitarydysfunctionthreemonthsormoreaftertraumaticbraininjury
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Patterns of pituitary dysfunction three months or more after traumatic brain injury

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