Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins (PHB1 and PHB2) assemble at the mitochondrial...

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Autores principales:	Misa Belser, David W. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prohibitin aging age-related diseases PHB1 PHB2 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/456b5efc6def4d0ebe679f4ec80704fb
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spelling	oai:doaj.org-article:456b5efc6def4d0ebe679f4ec80704fb2021-11-12T09:12:24ZRole of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases1664-802110.3389/fgene.2021.714228https://doaj.org/article/456b5efc6def4d0ebe679f4ec80704fb2021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.714228/fullhttps://doaj.org/toc/1664-8021A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins (PHB1 and PHB2) assemble at the mitochondrial inner membrane and are critical for mitochondrial homeostasis. In addition, prohibitins (PHBs) have diverse roles in cell and organismal biology. Here, we will discuss the role of PHBs in mitophagy, oxidative phosphorylation, cellular senescence, and apoptosis. We will also discuss the role of PHBs in modulating lifespan. In addition, we will review the links between PHBs and diseases of aging. Finally, we will discuss the emerging concept that PHBs may represent an attractive therapeutic target to counteract aging and age-onset disease.Misa BelserDavid W. WalkerDavid W. WalkerFrontiers Media S.A.articleprohibitinagingage-related diseasesPHB1PHB2GeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prohibitin aging age-related diseases PHB1 PHB2 Genetics QH426-470
spellingShingle	prohibitin aging age-related diseases PHB1 PHB2 Genetics QH426-470 Misa Belser David W. Walker David W. Walker Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
description	A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins (PHB1 and PHB2) assemble at the mitochondrial inner membrane and are critical for mitochondrial homeostasis. In addition, prohibitins (PHBs) have diverse roles in cell and organismal biology. Here, we will discuss the role of PHBs in mitophagy, oxidative phosphorylation, cellular senescence, and apoptosis. We will also discuss the role of PHBs in modulating lifespan. In addition, we will review the links between PHBs and diseases of aging. Finally, we will discuss the emerging concept that PHBs may represent an attractive therapeutic target to counteract aging and age-onset disease.
format	article
author	Misa Belser David W. Walker David W. Walker
author_facet	Misa Belser David W. Walker David W. Walker
author_sort	Misa Belser
title	Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
title_short	Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
title_full	Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
title_fullStr	Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
title_full_unstemmed	Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
title_sort	role of prohibitins in aging and therapeutic potential against age-related diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/456b5efc6def4d0ebe679f4ec80704fb
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Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

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