Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.

<h4>Purpose</h4>To investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC).<h4>Materials and methods&l...

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Autores principales:	Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/456c575d4afd4610b151ca9c1d589046
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spelling	oai:doaj.org-article:456c575d4afd4610b151ca9c1d5890462021-12-02T20:14:12ZChoroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.1932-620310.1371/journal.pone.0257763https://doaj.org/article/456c575d4afd4610b151ca9c1d5890462021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257763https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC).<h4>Materials and methods</h4>Enhanced depth imaging optical coherence tomography (EDI-OCT) was done in eyes with FIPED correlated to chronic CSC, fellow eyes, and also in healthy eyes from gender- and age-matched subjects. Eyes with FIPED were classified into two subgroups based on optical coherence tomography angiography (OCTA) findings: vFIPED and aFIPED. Different choroidal biomarkers such as subfoveal choroidal thickness (SFCT), total choroidal area (TCA), and choroidal vascular index (CVI) were compared between the groups.<h4>Results</h4>Forty-four eyes from 42 patients with chronic CSC and FIPED along with 40 eyes from 20 healthy subjects were included. OCTA identified vascularization in 14 eyes in the FIPED group (31.8%). Mean SFCT was higher in the FIPED group compared to two other groups (p = 0.005). In comparison to patients with aFIPED, patients with vFIPED had lower SFCT (p = 0.003) and higher CVI (p = 0.020) based on multivariate analysis.<h4>Conclusions</h4>It seems that measurement of CVI along with SFCT may help to differentiate aFIPED from vFIPED in patients with CSC. Further longitudinal studies would be required to confirm the clinical significance of these findings.Hooshang FaghihiAlireza MahmoudiElias Khalili PourNazanin EbrahimiadibKaveh FadakarFariba GhassemiAhmad MirshahiAlireza KhodabandeHassan KhojastehFatemeh BazvandMohammadreza Mehrabi BaharHamid Riazi-EsfahaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257763 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hooshang Faghihi Alireza Mahmoudi Elias Khalili Pour Nazanin Ebrahimiadib Kaveh Fadakar Fariba Ghassemi Ahmad Mirshahi Alireza Khodabande Hassan Khojasteh Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hamid Riazi-Esfahani Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
description	<h4>Purpose</h4>To investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC).<h4>Materials and methods</h4>Enhanced depth imaging optical coherence tomography (EDI-OCT) was done in eyes with FIPED correlated to chronic CSC, fellow eyes, and also in healthy eyes from gender- and age-matched subjects. Eyes with FIPED were classified into two subgroups based on optical coherence tomography angiography (OCTA) findings: vFIPED and aFIPED. Different choroidal biomarkers such as subfoveal choroidal thickness (SFCT), total choroidal area (TCA), and choroidal vascular index (CVI) were compared between the groups.<h4>Results</h4>Forty-four eyes from 42 patients with chronic CSC and FIPED along with 40 eyes from 20 healthy subjects were included. OCTA identified vascularization in 14 eyes in the FIPED group (31.8%). Mean SFCT was higher in the FIPED group compared to two other groups (p = 0.005). In comparison to patients with aFIPED, patients with vFIPED had lower SFCT (p = 0.003) and higher CVI (p = 0.020) based on multivariate analysis.<h4>Conclusions</h4>It seems that measurement of CVI along with SFCT may help to differentiate aFIPED from vFIPED in patients with CSC. Further longitudinal studies would be required to confirm the clinical significance of these findings.
format	article
author	Hooshang Faghihi Alireza Mahmoudi Elias Khalili Pour Nazanin Ebrahimiadib Kaveh Fadakar Fariba Ghassemi Ahmad Mirshahi Alireza Khodabande Hassan Khojasteh Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hamid Riazi-Esfahani
author_facet	Hooshang Faghihi Alireza Mahmoudi Elias Khalili Pour Nazanin Ebrahimiadib Kaveh Fadakar Fariba Ghassemi Ahmad Mirshahi Alireza Khodabande Hassan Khojasteh Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hamid Riazi-Esfahani
author_sort	Hooshang Faghihi
title	Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
title_short	Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
title_full	Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
title_fullStr	Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
title_full_unstemmed	Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.
title_sort	choroidal features in flat irregular pigment epithelial detachment associated with chronic central serous chorioretinopathy: avascular versus vascularized.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/456c575d4afd4610b151ca9c1d589046
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Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.

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