Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.

<h4>Introduction</h4>Platelet-activating factor (PAF) has a direct role as a mediator in the pathogenesis of various disorders with an inflammatory component, including those with allergic aetiology. The peripheral blood concentration of PAF is dynamically regulated by plasma PAF acetylh...

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Autores principales:	Krzysztof Łukasz Piwowarek, Agnieszka Rzeszotarska, Jolanta Łukasz Korsak, Aleksandra Juszkiewicz, Andrzej Chciałowski, Jerzy Kruszewski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/456cb67c3c574aa0b608d33f3582154b
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spelling	oai:doaj.org-article:456cb67c3c574aa0b608d33f3582154b2021-12-02T20:18:08ZClinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.1932-620310.1371/journal.pone.0256168https://doaj.org/article/456cb67c3c574aa0b608d33f3582154b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256168https://doaj.org/toc/1932-6203<h4>Introduction</h4>Platelet-activating factor (PAF) has a direct role as a mediator in the pathogenesis of various disorders with an inflammatory component, including those with allergic aetiology. The peripheral blood concentration of PAF is dynamically regulated by plasma PAF acetylhydrolase (PAF-AH). Previous research suggest that low activity of plasma PAF-AH could be a predictive marker for increased severity of some types of allergic hypersensitivity reactions-especially anaphylaxis. The purpose of the study was to evaluate the association between plasma PAF-AH activity and severity in patients with anaphylactic reactions following a wasp or bee sting.<h4>Materials and methods</h4>The study group of 89 patients was divided into two subgroups depending on the increasing severity of the most severe anaphylactic reaction in the past, which was assessed according to the Müller's scale. The first subgroup included participants with a history of hypersensitivity reactions up to grade II. The second subgroup consisted of patients who have experienced at least one grade III or IV reactions in the past. A control group of 20 people was established. Plasma PAF-AH activity was measured using a colorimetric method.<h4>Results</h4>It has been observed that plasma activity of platelet-activating factor acetylhydrolase was significantly lower in patients with anaphylaxis history compared to the control group with negative atopic history (on average 21.38 nmol/min/ml for the control group, 9.47 nmol/min/ml for the first subgroup and 10.16 nmol/min/ml for the second subgroup, in both cases p < 0.0001).<h4>Conclusion</h4>The plasma activity of PAF-AH is a promising parameter that can help to distinguish a group of patients not threatened with development of anaphylaxis and not requiring laborious or expensive prophylactic procedures.Krzysztof Łukasz PiwowarekAgnieszka RzeszotarskaJolanta Łukasz KorsakAleksandra JuszkiewiczAndrzej ChciałowskiJerzy KruszewskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256168 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Krzysztof Łukasz Piwowarek Agnieszka Rzeszotarska Jolanta Łukasz Korsak Aleksandra Juszkiewicz Andrzej Chciałowski Jerzy Kruszewski Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
description	<h4>Introduction</h4>Platelet-activating factor (PAF) has a direct role as a mediator in the pathogenesis of various disorders with an inflammatory component, including those with allergic aetiology. The peripheral blood concentration of PAF is dynamically regulated by plasma PAF acetylhydrolase (PAF-AH). Previous research suggest that low activity of plasma PAF-AH could be a predictive marker for increased severity of some types of allergic hypersensitivity reactions-especially anaphylaxis. The purpose of the study was to evaluate the association between plasma PAF-AH activity and severity in patients with anaphylactic reactions following a wasp or bee sting.<h4>Materials and methods</h4>The study group of 89 patients was divided into two subgroups depending on the increasing severity of the most severe anaphylactic reaction in the past, which was assessed according to the Müller's scale. The first subgroup included participants with a history of hypersensitivity reactions up to grade II. The second subgroup consisted of patients who have experienced at least one grade III or IV reactions in the past. A control group of 20 people was established. Plasma PAF-AH activity was measured using a colorimetric method.<h4>Results</h4>It has been observed that plasma activity of platelet-activating factor acetylhydrolase was significantly lower in patients with anaphylaxis history compared to the control group with negative atopic history (on average 21.38 nmol/min/ml for the control group, 9.47 nmol/min/ml for the first subgroup and 10.16 nmol/min/ml for the second subgroup, in both cases p < 0.0001).<h4>Conclusion</h4>The plasma activity of PAF-AH is a promising parameter that can help to distinguish a group of patients not threatened with development of anaphylaxis and not requiring laborious or expensive prophylactic procedures.
format	article
author	Krzysztof Łukasz Piwowarek Agnieszka Rzeszotarska Jolanta Łukasz Korsak Aleksandra Juszkiewicz Andrzej Chciałowski Jerzy Kruszewski
author_facet	Krzysztof Łukasz Piwowarek Agnieszka Rzeszotarska Jolanta Łukasz Korsak Aleksandra Juszkiewicz Andrzej Chciałowski Jerzy Kruszewski
author_sort	Krzysztof Łukasz Piwowarek
title	Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
title_short	Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
title_full	Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
title_fullStr	Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
title_full_unstemmed	Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
title_sort	clinical significance of plasma paf acetylhydrolase activity measurements as a biomarker of anaphylaxis: cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/456cb67c3c574aa0b608d33f3582154b
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Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.

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