Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast

Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast

Abstract The final step in post-translational processing of Ras and Rho GTPases involves methylation of the prenylated cysteine residue by an isoprenylcysteine-O-carboxyl methyltransferase (ICMT). ICMT activity is essential for cell growth and development in higher eukaryotes, and inhibition of GTPa...

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Autores principales: Alejandro Franco, Teresa Soto, Rebeca Martín-García, Marisa Madrid, Beatriz Vázquez-Marín, Jero Vicente-Soler, Pedro M. Coll, Mariano Gacto, Pilar Pérez, José Cansado
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/456d2353d713453aa2b34b2014f01f07
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