Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity

Abstract It remains unclear whether leukocyte-related parameters could be used as biomarkers to differentiate metabolically unhealthy overweight/obesity (MUO) from metabolically healthy overweight/obesity (MHO). We aimed to examine the differences in the distribution of leukocyte-related parameters...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shan-Shan Zhang, Xue-Jiao Yang, Qing-Hua Ma, Yong Xu, Xing Chen, Pei Wang, Chen-Wei Pan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/456d83afb5a54393b87830b8add57528
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:456d83afb5a54393b87830b8add57528
record_format dspace
spelling oai:doaj.org-article:456d83afb5a54393b87830b8add575282021-12-02T15:53:42ZLeukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity10.1038/s41598-021-84367-72045-2322https://doaj.org/article/456d83afb5a54393b87830b8add575282021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84367-7https://doaj.org/toc/2045-2322Abstract It remains unclear whether leukocyte-related parameters could be used as biomarkers to differentiate metabolically unhealthy overweight/obesity (MUO) from metabolically healthy overweight/obesity (MHO). We aimed to examine the differences in the distribution of leukocyte-related parameters between older adults with MHO and MUO and the correlations of leukocyte-related parameters with individual components of metabolic abnormality. In the Weitang Geriatric Diseases Study on older Chinese adults aged 60 years or above, 404 individuals with MHO and 480 with MUO contributed to the analysis. Overweight/obesity was defined as body mass index (BMI) of 25 kg/m2 or more. MHO and MUO were discriminated based on the Adult Treatment Panel III (ATP III) criteria. Leukocyte-related parameters were assessed using an automated hematology analyzer. All leukocyte-related parameters except monocytes were elevated in MUO group compared with MHO group (all P < 0.05). The prevalence of MUO increased by 24% with each 109/L increase of leukocytes after adjusting for confounders in the multiple-adjusted model (P < 0.01) and each unit elevation of other parameters except lymphocytes and monocytes were significantly associated with the presence of MUO (all P < 0.01). Trend tests revealed a linear trend for the association between MUO and all the leukocyte-related parameters (all P for trend < 0.05). Significant interactions between leukocyte-related parameters and sex on the presence of MUO were observed (all P value for interaction < 0.05). Higher leukocyte-related parameters were found in patients with MUO than those with MHO and were associated with higher prevalence of MUO which seems to be sex-dependent. Further studies are needed to see whether these parameters could be used as biomarkers for the screening or diagnosis for MUO in clinical or public health practice.Shan-Shan ZhangXue-Jiao YangQing-Hua MaYong XuXing ChenPei WangChen-Wei PanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shan-Shan Zhang
Xue-Jiao Yang
Qing-Hua Ma
Yong Xu
Xing Chen
Pei Wang
Chen-Wei Pan
Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
description Abstract It remains unclear whether leukocyte-related parameters could be used as biomarkers to differentiate metabolically unhealthy overweight/obesity (MUO) from metabolically healthy overweight/obesity (MHO). We aimed to examine the differences in the distribution of leukocyte-related parameters between older adults with MHO and MUO and the correlations of leukocyte-related parameters with individual components of metabolic abnormality. In the Weitang Geriatric Diseases Study on older Chinese adults aged 60 years or above, 404 individuals with MHO and 480 with MUO contributed to the analysis. Overweight/obesity was defined as body mass index (BMI) of 25 kg/m2 or more. MHO and MUO were discriminated based on the Adult Treatment Panel III (ATP III) criteria. Leukocyte-related parameters were assessed using an automated hematology analyzer. All leukocyte-related parameters except monocytes were elevated in MUO group compared with MHO group (all P < 0.05). The prevalence of MUO increased by 24% with each 109/L increase of leukocytes after adjusting for confounders in the multiple-adjusted model (P < 0.01) and each unit elevation of other parameters except lymphocytes and monocytes were significantly associated with the presence of MUO (all P < 0.01). Trend tests revealed a linear trend for the association between MUO and all the leukocyte-related parameters (all P for trend < 0.05). Significant interactions between leukocyte-related parameters and sex on the presence of MUO were observed (all P value for interaction < 0.05). Higher leukocyte-related parameters were found in patients with MUO than those with MHO and were associated with higher prevalence of MUO which seems to be sex-dependent. Further studies are needed to see whether these parameters could be used as biomarkers for the screening or diagnosis for MUO in clinical or public health practice.
format article
author Shan-Shan Zhang
Xue-Jiao Yang
Qing-Hua Ma
Yong Xu
Xing Chen
Pei Wang
Chen-Wei Pan
author_facet Shan-Shan Zhang
Xue-Jiao Yang
Qing-Hua Ma
Yong Xu
Xing Chen
Pei Wang
Chen-Wei Pan
author_sort Shan-Shan Zhang
title Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
title_short Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
title_full Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
title_fullStr Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
title_full_unstemmed Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
title_sort leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/456d83afb5a54393b87830b8add57528
work_keys_str_mv AT shanshanzhang leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT xuejiaoyang leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT qinghuama leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT yongxu leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT xingchen leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT peiwang leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
AT chenweipan leukocyterelatedparametersinolderadultswithmetabolicallyhealthyandunhealthyoverweightorobesity
_version_ 1718385506487631872