RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.

Resection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about processing of random "dirty-ended" DSBs created by DNA damaging agents s...

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Detalles Bibliográficos
Autores principales: Jim Westmoreland, Wenjian Ma, Yan Yan, Kelly Van Hulle, Anna Malkova, Michael A Resnick
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/456e7452b8874470b01a8e61f3d54a07
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