Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic...

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Autores principales: Axel von Kamp, Steffen Klamt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/456fae5b52564f9792b010af854f581f
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spelling oai:doaj.org-article:456fae5b52564f9792b010af854f581f2021-12-02T17:06:07ZGrowth-coupled overproduction is feasible for almost all metabolites in five major production organisms10.1038/ncomms159562041-1723https://doaj.org/article/456fae5b52564f9792b010af854f581f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15956https://doaj.org/toc/2041-1723Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.Axel von KampSteffen KlamtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Axel von Kamp
Steffen Klamt
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
description Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.
format article
author Axel von Kamp
Steffen Klamt
author_facet Axel von Kamp
Steffen Klamt
author_sort Axel von Kamp
title Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_short Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_full Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_fullStr Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_full_unstemmed Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_sort growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/456fae5b52564f9792b010af854f581f
work_keys_str_mv AT axelvonkamp growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms
AT steffenklamt growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms
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