Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic...
Guardado en:
Autores principales: | , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/456fae5b52564f9792b010af854f581f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:456fae5b52564f9792b010af854f581f |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:456fae5b52564f9792b010af854f581f2021-12-02T17:06:07ZGrowth-coupled overproduction is feasible for almost all metabolites in five major production organisms10.1038/ncomms159562041-1723https://doaj.org/article/456fae5b52564f9792b010af854f581f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15956https://doaj.org/toc/2041-1723Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.Axel von KampSteffen KlamtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Axel von Kamp Steffen Klamt Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
description |
Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites. |
format |
article |
author |
Axel von Kamp Steffen Klamt |
author_facet |
Axel von Kamp Steffen Klamt |
author_sort |
Axel von Kamp |
title |
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
title_short |
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
title_full |
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
title_fullStr |
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
title_full_unstemmed |
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
title_sort |
growth-coupled overproduction is feasible for almost all metabolites in five major production organisms |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/456fae5b52564f9792b010af854f581f |
work_keys_str_mv |
AT axelvonkamp growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms AT steffenklamt growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms |
_version_ |
1718381726386880512 |