Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic...

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Main Authors:	Axel von Kamp, Steffen Klamt
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/456fae5b52564f9792b010af854f581f
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spelling	oai:doaj.org-article:456fae5b52564f9792b010af854f581f2021-12-02T17:06:07ZGrowth-coupled overproduction is feasible for almost all metabolites in five major production organisms10.1038/ncomms159562041-1723https://doaj.org/article/456fae5b52564f9792b010af854f581f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15956https://doaj.org/toc/2041-1723Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.Axel von KampSteffen KlamtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Axel von Kamp Steffen Klamt Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
description	Coupling of growth and product synthesis is an important principle in metabolic engineering, but its range of applicability is unclear. Here, the authors use a dedicated computational framework to study the feasibility of coupling the production of metabolites to growth in the genome-scale metabolic models of five production organisms, and show that coupling can be achieved for most metabolites.
format	article
author	Axel von Kamp Steffen Klamt
author_facet	Axel von Kamp Steffen Klamt
author_sort	Axel von Kamp
title	Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_short	Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_full	Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_fullStr	Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_full_unstemmed	Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
title_sort	growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/456fae5b52564f9792b010af854f581f
work_keys_str_mv	AT axelvonkamp growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms AT steffenklamt growthcoupledoverproductionisfeasibleforalmostallmetabolitesinfivemajorproductionorganisms
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Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

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