Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.

The aim of this work was to evaluate the capabilities of Debye theory combined with Finite Difference Time Domain (FDTD) methods to simulate the terahertz (THz) response of breast tissues. Being able to accurately model breast tissues in the THz regime would facilitate the understanding of image con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anthony J Fitzgerald, Emma Pickwell-MacPherson, Vincent P Wallace
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4579d7d1d48949eeb1ff5736fe708651
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4579d7d1d48949eeb1ff5736fe708651
record_format	dspace
spelling	oai:doaj.org-article:4579d7d1d48949eeb1ff5736fe7086512021-11-25T06:08:53ZUse of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.1932-620310.1371/journal.pone.0099291https://doaj.org/article/4579d7d1d48949eeb1ff5736fe7086512014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25010734/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of this work was to evaluate the capabilities of Debye theory combined with Finite Difference Time Domain (FDTD) methods to simulate the terahertz (THz) response of breast tissues. Being able to accurately model breast tissues in the THz regime would facilitate the understanding of image contrast parameters used in THz imaging of breast cancer. As a test case, the model was first validated using liquid water and simulated reflection pulses were compared to experimental measured pulses with very good agreement (p = 1.00). The responses of normal and cancerous breast tissues were simulated with Debye properties and the correlation with measured data was still high for tumour (p = 0.98) and less so for normal breast (p = 0.82). Sections of the time domain pulses showed clear differences that were also evident in the comparison of pulse parameter values. These deviations may arise from the presence of adipose and other inhomogeneities in the breast tissue that are not accounted for when using the Debye model. In conclusion, the study demonstrates the power of the model for simulating THz reflection imaging; however, for biological tissues extra Debye terms or a more detailed theory may be required to link THz image contrast to physiological composition and structural changes of breast tissue associated with differences between normal and tumour tissues.Anthony J FitzgeraldEmma Pickwell-MacPhersonVincent P WallacePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e99291 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anthony J Fitzgerald Emma Pickwell-MacPherson Vincent P Wallace Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
description	The aim of this work was to evaluate the capabilities of Debye theory combined with Finite Difference Time Domain (FDTD) methods to simulate the terahertz (THz) response of breast tissues. Being able to accurately model breast tissues in the THz regime would facilitate the understanding of image contrast parameters used in THz imaging of breast cancer. As a test case, the model was first validated using liquid water and simulated reflection pulses were compared to experimental measured pulses with very good agreement (p = 1.00). The responses of normal and cancerous breast tissues were simulated with Debye properties and the correlation with measured data was still high for tumour (p = 0.98) and less so for normal breast (p = 0.82). Sections of the time domain pulses showed clear differences that were also evident in the comparison of pulse parameter values. These deviations may arise from the presence of adipose and other inhomogeneities in the breast tissue that are not accounted for when using the Debye model. In conclusion, the study demonstrates the power of the model for simulating THz reflection imaging; however, for biological tissues extra Debye terms or a more detailed theory may be required to link THz image contrast to physiological composition and structural changes of breast tissue associated with differences between normal and tumour tissues.
format	article
author	Anthony J Fitzgerald Emma Pickwell-MacPherson Vincent P Wallace
author_facet	Anthony J Fitzgerald Emma Pickwell-MacPherson Vincent P Wallace
author_sort	Anthony J Fitzgerald
title	Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
title_short	Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
title_full	Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
title_fullStr	Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
title_full_unstemmed	Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
title_sort	use of finite difference time domain simulations and debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4579d7d1d48949eeb1ff5736fe708651
work_keys_str_mv	AT anthonyjfitzgerald useoffinitedifferencetimedomainsimulationsanddebyetheoryformodellingtheterahertzreflectionresponseofnormalandtumourbreasttissue AT emmapickwellmacpherson useoffinitedifferencetimedomainsimulationsanddebyetheoryformodellingtheterahertzreflectionresponseofnormalandtumourbreasttissue AT vincentpwallace useoffinitedifferencetimedomainsimulationsanddebyetheoryformodellingtheterahertzreflectionresponseofnormalandtumourbreasttissue
_version_	1718414097276469248

Use of finite difference time domain simulations and Debye theory for modelling the terahertz reflection response of normal and tumour breast tissue.

Ejemplares similares