Noncytotoxic functions of killer cell granzymes in viral infections.

Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans. This granule-exocytosis pathway subsumes a well-established mechanism in which targ...

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Auteurs principaux: Lisanne C de Jong, Sandra Crnko, Toine Ten Broeke, Niels Bovenschen
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
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Accès en ligne:https://doaj.org/article/457ae3a589ce4f15a2f5f66d5c90e0e5
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