PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics

Abstract Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer epithelium, making it a promising target for molecular imaging and therapy. Recently, several studies found unexpected PSMA radiotracer uptake by thyroid tumors, including radioiodine-refractory (RAIR) cancers. PS...

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Autores principales:	Andrey Bychkov, Usanee Vutrapongwatana, Supatporn Tepmongkol, Somboon Keelawat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/457c0d0617954d1087ded1eb89dbbbec
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spelling	oai:doaj.org-article:457c0d0617954d1087ded1eb89dbbbec2021-12-02T15:05:45ZPSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics10.1038/s41598-017-05481-z2045-2322https://doaj.org/article/457c0d0617954d1087ded1eb89dbbbec2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05481-zhttps://doaj.org/toc/2045-2322Abstract Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer epithelium, making it a promising target for molecular imaging and therapy. Recently, several studies found unexpected PSMA radiotracer uptake by thyroid tumors, including radioiodine-refractory (RAIR) cancers. PSMA expression was reported in tumor-associated endothelium of various malignancies, however it has not been systematically addressed in thyroid tumors. We found that PSMA was frequently expressed in microvessels of thyroid tumors (120/267), but not in benign thyroid tissue. PSMA expression in neovasculature was highly irregular ranging from 19% in benign tumors to over 50% in thyroid cancer. Such heterogeneity was not directly attributed to endothelial cell proliferation as confirmed by immunostaining with proliferation-associated endothelial marker CD105. PSMA expression was associated with tumor size (p = 0.02) and vascular invasion in follicular carcinoma (p = 0.03), but not with other baseline histological, and clinical parameters. Significant translational implication is that RAIR tumors and high-grade cancers maintain high level of PSMA expression, and can be targeted by PSMA ligand radiopharmaceuticals. Our study predicts several pitfalls potentially associated with PSMA imaging of the thyroid, such as low expression in oncocytic tumors, absence of organ specificity, and PSMA-positivity in dendritic cells of chronic thyroiditis, which is described for the first time.Andrey BychkovUsanee VutrapongwatanaSupatporn TepmongkolSomboon KeelawatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrey Bychkov Usanee Vutrapongwatana Supatporn Tepmongkol Somboon Keelawat PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
description	Abstract Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer epithelium, making it a promising target for molecular imaging and therapy. Recently, several studies found unexpected PSMA radiotracer uptake by thyroid tumors, including radioiodine-refractory (RAIR) cancers. PSMA expression was reported in tumor-associated endothelium of various malignancies, however it has not been systematically addressed in thyroid tumors. We found that PSMA was frequently expressed in microvessels of thyroid tumors (120/267), but not in benign thyroid tissue. PSMA expression in neovasculature was highly irregular ranging from 19% in benign tumors to over 50% in thyroid cancer. Such heterogeneity was not directly attributed to endothelial cell proliferation as confirmed by immunostaining with proliferation-associated endothelial marker CD105. PSMA expression was associated with tumor size (p = 0.02) and vascular invasion in follicular carcinoma (p = 0.03), but not with other baseline histological, and clinical parameters. Significant translational implication is that RAIR tumors and high-grade cancers maintain high level of PSMA expression, and can be targeted by PSMA ligand radiopharmaceuticals. Our study predicts several pitfalls potentially associated with PSMA imaging of the thyroid, such as low expression in oncocytic tumors, absence of organ specificity, and PSMA-positivity in dendritic cells of chronic thyroiditis, which is described for the first time.
format	article
author	Andrey Bychkov Usanee Vutrapongwatana Supatporn Tepmongkol Somboon Keelawat
author_facet	Andrey Bychkov Usanee Vutrapongwatana Supatporn Tepmongkol Somboon Keelawat
author_sort	Andrey Bychkov
title	PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
title_short	PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
title_full	PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
title_fullStr	PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
title_full_unstemmed	PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
title_sort	psma expression by microvasculature of thyroid tumors – potential implications for psma theranostics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/457c0d0617954d1087ded1eb89dbbbec
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PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics

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