Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster. Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program. We, first, confirmed that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Taro Ueno, Naoki Masuda, Shoen Kume, Kazuhiko Kume
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/457fbf0ee7094712be9681bb8fb14178
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:457fbf0ee7094712be9681bb8fb14178
record_format	dspace
spelling	oai:doaj.org-article:457fbf0ee7094712be9681bb8fb141782021-11-18T07:27:54ZDopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.1932-620310.1371/journal.pone.0032007https://doaj.org/article/457fbf0ee7094712be9681bb8fb141782012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22359653/?tool=EBIhttps://doaj.org/toc/1932-6203We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster. Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program. We, first, confirmed that rest bout durations followed long-tailed (i.e., power-law) distributions, whereas activity bout durations did not with a strict method described by Clauset et al. We also studied the effects of circadian rhythm and ambient temperature on rest bouts and activity bouts. The fraction of activity significantly increased during subjective day and at high temperature, but the power-law exponent of the rest bout distribution was not affected. The reduction in rest was realized by reduction in long rest bouts. The distribution of activity bouts did not change drastically under the above mentioned conditions. We then assessed the effects of dopamine. The distribution of rest bouts became less long-tailed and the time spent in activity significantly increased after the augmentation of dopamine signaling. Administration of a dopamine biosynthesis inhibitor yielded the opposite effects. However, the distribution of activity bouts did not contribute to the changes. These results suggest that the modulation of locomotor behavior by dopamine is predominantly controlled by changing the duration of rest bouts, rather than the duration of activity bouts.Taro UenoNaoki MasudaShoen KumeKazuhiko KumePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32007 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taro Ueno Naoki Masuda Shoen Kume Kazuhiko Kume Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
description	We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster. Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program. We, first, confirmed that rest bout durations followed long-tailed (i.e., power-law) distributions, whereas activity bout durations did not with a strict method described by Clauset et al. We also studied the effects of circadian rhythm and ambient temperature on rest bouts and activity bouts. The fraction of activity significantly increased during subjective day and at high temperature, but the power-law exponent of the rest bout distribution was not affected. The reduction in rest was realized by reduction in long rest bouts. The distribution of activity bouts did not change drastically under the above mentioned conditions. We then assessed the effects of dopamine. The distribution of rest bouts became less long-tailed and the time spent in activity significantly increased after the augmentation of dopamine signaling. Administration of a dopamine biosynthesis inhibitor yielded the opposite effects. However, the distribution of activity bouts did not contribute to the changes. These results suggest that the modulation of locomotor behavior by dopamine is predominantly controlled by changing the duration of rest bouts, rather than the duration of activity bouts.
format	article
author	Taro Ueno Naoki Masuda Shoen Kume Kazuhiko Kume
author_facet	Taro Ueno Naoki Masuda Shoen Kume Kazuhiko Kume
author_sort	Taro Ueno
title	Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
title_short	Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
title_full	Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
title_fullStr	Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
title_full_unstemmed	Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.
title_sort	dopamine modulates the rest period length without perturbation of its power law distribution in drosophila melanogaster.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/457fbf0ee7094712be9681bb8fb14178
work_keys_str_mv	AT taroueno dopaminemodulatestherestperiodlengthwithoutperturbationofitspowerlawdistributionindrosophilamelanogaster AT naokimasuda dopaminemodulatestherestperiodlengthwithoutperturbationofitspowerlawdistributionindrosophilamelanogaster AT shoenkume dopaminemodulatestherestperiodlengthwithoutperturbationofitspowerlawdistributionindrosophilamelanogaster AT kazuhikokume dopaminemodulatestherestperiodlengthwithoutperturbationofitspowerlawdistributionindrosophilamelanogaster
_version_	1718423404611108864

Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

Ejemplares similares