Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 signaling.

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Autores principales:	Rhianna C. Laker, Joshua C. Drake, Rebecca J. Wilson, Vitor A. Lira, Bevan M. Lewellen, Karen A. Ryall, Carleigh C. Fisher, Mei Zhang, Jeffrey J. Saucerman, Laurie J. Goodyear, Mondira Kundu, Zhen Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45800b0013144c79a5f7f403114864d6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:45800b0013144c79a5f7f403114864d62021-12-02T14:41:10ZAmpk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy10.1038/s41467-017-00520-92041-1723https://doaj.org/article/45800b0013144c79a5f7f403114864d62017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00520-9https://doaj.org/toc/2041-1723Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 signaling.Rhianna C. LakerJoshua C. DrakeRebecca J. WilsonVitor A. LiraBevan M. LewellenKaren A. RyallCarleigh C. FisherMei ZhangJeffrey J. SaucermanLaurie J. GoodyearMondira KunduZhen YanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rhianna C. Laker Joshua C. Drake Rebecca J. Wilson Vitor A. Lira Bevan M. Lewellen Karen A. Ryall Carleigh C. Fisher Mei Zhang Jeffrey J. Saucerman Laurie J. Goodyear Mondira Kundu Zhen Yan Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
description	Exercise is associated with biogenesis and removal of dysfunctional mitochondria. Here the authors use a mitochondrial reporter gene to demonstrate the occurrence of mitophagy following exercise in mice, and show this is dependent on AMPK and ULK1 signaling.
format	article
author	Rhianna C. Laker Joshua C. Drake Rebecca J. Wilson Vitor A. Lira Bevan M. Lewellen Karen A. Ryall Carleigh C. Fisher Mei Zhang Jeffrey J. Saucerman Laurie J. Goodyear Mondira Kundu Zhen Yan
author_facet	Rhianna C. Laker Joshua C. Drake Rebecca J. Wilson Vitor A. Lira Bevan M. Lewellen Karen A. Ryall Carleigh C. Fisher Mei Zhang Jeffrey J. Saucerman Laurie J. Goodyear Mondira Kundu Zhen Yan
author_sort	Rhianna C. Laker
title	Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
title_short	Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
title_full	Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
title_fullStr	Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
title_full_unstemmed	Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
title_sort	ampk phosphorylation of ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/45800b0013144c79a5f7f403114864d6
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Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

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