Sex Reporting in Preclinical Microbiological and Immunological Research

ABSTRACT Both sex (i.e., biological construct of male and female) and gender (i.e., social construct of masculine and feminine) impact the pathogenesis of diseases, including those caused by microbial infections. Following the 2015 NIH policy for consideration of sex as a biological variable in prec...

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Autores principales:	Tanvi Potluri, Kyrra Engle, Ashley L. Fink, Landon G. vom Steeg, Sabra L. Klein
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	immunology microbiology sex reporting Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4580945c418c4a818be234ecf04199cd
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spelling	oai:doaj.org-article:4580945c418c4a818be234ecf04199cd2021-11-15T15:51:56ZSex Reporting in Preclinical Microbiological and Immunological Research10.1128/mBio.01868-172150-7511https://doaj.org/article/4580945c418c4a818be234ecf04199cd2017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01868-17https://doaj.org/toc/2150-7511ABSTRACT Both sex (i.e., biological construct of male and female) and gender (i.e., social construct of masculine and feminine) impact the pathogenesis of diseases, including those caused by microbial infections. Following the 2015 NIH policy for consideration of sex as a biological variable in preclinical research, in 2018, authors of papers published in primary-research American Society for Microbiology (ASM) journals will be asked to report the sex of the research subjects and animals and of materials derived directly from them. To address the need for sex reporting in ASM journals, we systematically reviewed 2,928 primary-research articles published in six primary-research ASM journals (Antimicrobial Agents and Chemotherapy, Clinical and Vaccine Immunology, Infection and Immunity, Journal of Bacteriology, Journal of Virology, and mBio) in 2016. Approximately 37% of animal studies and 9% of primary cell culture papers published in 2016 would have been affected by the new sex-reporting policy. For animal studies (i.e., studies with any nonhuman vertebrate hosts), most published papers either did not report the sex of the animals or used only female animals, and a minority used only males or both sexes. For published studies using primary cells from diverse animal species (i.e., humans and nonhuman vertebrates), almost all studies failed to report the sex of donors from which the cells were isolated. We believe that reporting the sex of animals and even of the donors of derived cells could improve the rigor and reproducibility of research conducted in microbiology and immunology and published in ASM journals.Tanvi PotluriKyrra EngleAshley L. FinkLandon G. vom SteegSabra L. KleinAmerican Society for Microbiologyarticleimmunologymicrobiologysex reportingMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunology microbiology sex reporting Microbiology QR1-502
spellingShingle	immunology microbiology sex reporting Microbiology QR1-502 Tanvi Potluri Kyrra Engle Ashley L. Fink Landon G. vom Steeg Sabra L. Klein Sex Reporting in Preclinical Microbiological and Immunological Research
description	ABSTRACT Both sex (i.e., biological construct of male and female) and gender (i.e., social construct of masculine and feminine) impact the pathogenesis of diseases, including those caused by microbial infections. Following the 2015 NIH policy for consideration of sex as a biological variable in preclinical research, in 2018, authors of papers published in primary-research American Society for Microbiology (ASM) journals will be asked to report the sex of the research subjects and animals and of materials derived directly from them. To address the need for sex reporting in ASM journals, we systematically reviewed 2,928 primary-research articles published in six primary-research ASM journals (Antimicrobial Agents and Chemotherapy, Clinical and Vaccine Immunology, Infection and Immunity, Journal of Bacteriology, Journal of Virology, and mBio) in 2016. Approximately 37% of animal studies and 9% of primary cell culture papers published in 2016 would have been affected by the new sex-reporting policy. For animal studies (i.e., studies with any nonhuman vertebrate hosts), most published papers either did not report the sex of the animals or used only female animals, and a minority used only males or both sexes. For published studies using primary cells from diverse animal species (i.e., humans and nonhuman vertebrates), almost all studies failed to report the sex of donors from which the cells were isolated. We believe that reporting the sex of animals and even of the donors of derived cells could improve the rigor and reproducibility of research conducted in microbiology and immunology and published in ASM journals.
format	article
author	Tanvi Potluri Kyrra Engle Ashley L. Fink Landon G. vom Steeg Sabra L. Klein
author_facet	Tanvi Potluri Kyrra Engle Ashley L. Fink Landon G. vom Steeg Sabra L. Klein
author_sort	Tanvi Potluri
title	Sex Reporting in Preclinical Microbiological and Immunological Research
title_short	Sex Reporting in Preclinical Microbiological and Immunological Research
title_full	Sex Reporting in Preclinical Microbiological and Immunological Research
title_fullStr	Sex Reporting in Preclinical Microbiological and Immunological Research
title_full_unstemmed	Sex Reporting in Preclinical Microbiological and Immunological Research
title_sort	sex reporting in preclinical microbiological and immunological research
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/4580945c418c4a818be234ecf04199cd
work_keys_str_mv	AT tanvipotluri sexreportinginpreclinicalmicrobiologicalandimmunologicalresearch AT kyrraengle sexreportinginpreclinicalmicrobiologicalandimmunologicalresearch AT ashleylfink sexreportinginpreclinicalmicrobiologicalandimmunologicalresearch AT landongvomsteeg sexreportinginpreclinicalmicrobiologicalandimmunologicalresearch AT sabralklein sexreportinginpreclinicalmicrobiologicalandimmunologicalresearch
_version_	1718427271241400320

Sex Reporting in Preclinical Microbiological and Immunological Research

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