TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine

Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103−CD11b+ cells and that they contribute to the generation of Th17 and regulatory T c...

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Autores principales: C. C. Bain, J. Montgomery, C. L. Scott, J. M. Kel, M. J. H. Girard-Madoux, L. Martens, T. F. P. Zangerle-Murray, J. Ober-Blöbaum, D. Lindenbergh-Kortleve, J. N. Samsom, S. Henri, T. Lawrence, Y. Saeys, B. Malissen, M. Dalod, B. E. Clausen, A. McI. Mowat
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/4581ca774d5841c890557730e8ad8bd2
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Sumario:Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103−CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells

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