Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein and has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. However, the biological role and clinical behavior of ANXA1 in glioma remain...

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Autores principales:	Zenghui Qian, Wenhua Fan, Fanlin Meng, Zhiyan Sun, Guanzhang Li, You Zhai, Yuanhao Chang, Changlin Yang, Fan Zeng, Ruichao Chai, Fan Wu, Zheng Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glioma clinical behaviors immune macrophage mesenchymal Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4582859f6da4444ca609fe4413c9d783
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spelling	oai:doaj.org-article:4582859f6da4444ca609fe4413c9d7832021-12-01T13:57:36ZMolecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients2296-634X10.3389/fcell.2021.777182https://doaj.org/article/4582859f6da4444ca609fe4413c9d7832021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.777182/fullhttps://doaj.org/toc/2296-634XAnnexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein and has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. However, the biological role and clinical behavior of ANXA1 in glioma remain unclear. In this study, RNA-seq (n = 1018 cases) and whole-exome sequencing (WES) (n = 286 cases) data on a Chinese cohort, RNA-seq data with different histological regions of glioblastoma blocks (n = 270 cases), and scRNA-seq data (n = 7630 cells) were used. We used the R software to perform statistical calculations and graph rendering. We found that ANXA1 is closely related to the malignant progression in gliomas. Meanwhile, ANXA1 is significantly associated with clinical behavior. Furthermore, the mutational profile revealed that glioma subtypes classified by ANXA1 expression showed distinct genetic features. Functional analyses suggest that ANXA1 correlates with the immune-related function and cancer hallmark. At a single-cell level, we found that ANXA1 is highly expressed in M2 macrophages and tumor cells of the mesenchymal subtype. Importantly, our result suggested that ANXA1 expression is significant with the patient’s survival outcome. Our study revealed that ANXA1 was closely related to immune response. ANXA1 plays a key factor in M2 macrophages and MES tumor cells. Patients with lower ANXA1 expression levels tended to experience improved survival. ANXA1 may become a valuable factor for the diagnosis and treatment of gliomas in clinical practice.Zenghui QianWenhua FanWenhua FanFanlin MengZhiyan SunGuanzhang LiYou ZhaiYuanhao ChangChanglin YangFan ZengFan ZengRuichao ChaiRuichao ChaiFan WuFan WuZheng ZhaoZheng ZhaoFrontiers Media S.A.articlegliomaclinical behaviorsimmunemacrophagemesenchymalBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioma clinical behaviors immune macrophage mesenchymal Biology (General) QH301-705.5
spellingShingle	glioma clinical behaviors immune macrophage mesenchymal Biology (General) QH301-705.5 Zenghui Qian Wenhua Fan Wenhua Fan Fanlin Meng Zhiyan Sun Guanzhang Li You Zhai Yuanhao Chang Changlin Yang Fan Zeng Fan Zeng Ruichao Chai Ruichao Chai Fan Wu Fan Wu Zheng Zhao Zheng Zhao Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
description	Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein and has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. However, the biological role and clinical behavior of ANXA1 in glioma remain unclear. In this study, RNA-seq (n = 1018 cases) and whole-exome sequencing (WES) (n = 286 cases) data on a Chinese cohort, RNA-seq data with different histological regions of glioblastoma blocks (n = 270 cases), and scRNA-seq data (n = 7630 cells) were used. We used the R software to perform statistical calculations and graph rendering. We found that ANXA1 is closely related to the malignant progression in gliomas. Meanwhile, ANXA1 is significantly associated with clinical behavior. Furthermore, the mutational profile revealed that glioma subtypes classified by ANXA1 expression showed distinct genetic features. Functional analyses suggest that ANXA1 correlates with the immune-related function and cancer hallmark. At a single-cell level, we found that ANXA1 is highly expressed in M2 macrophages and tumor cells of the mesenchymal subtype. Importantly, our result suggested that ANXA1 expression is significant with the patient’s survival outcome. Our study revealed that ANXA1 was closely related to immune response. ANXA1 plays a key factor in M2 macrophages and MES tumor cells. Patients with lower ANXA1 expression levels tended to experience improved survival. ANXA1 may become a valuable factor for the diagnosis and treatment of gliomas in clinical practice.
format	article
author	Zenghui Qian Wenhua Fan Wenhua Fan Fanlin Meng Zhiyan Sun Guanzhang Li You Zhai Yuanhao Chang Changlin Yang Fan Zeng Fan Zeng Ruichao Chai Ruichao Chai Fan Wu Fan Wu Zheng Zhao Zheng Zhao
author_facet	Zenghui Qian Wenhua Fan Wenhua Fan Fanlin Meng Zhiyan Sun Guanzhang Li You Zhai Yuanhao Chang Changlin Yang Fan Zeng Fan Zeng Ruichao Chai Ruichao Chai Fan Wu Fan Wu Zheng Zhao Zheng Zhao
author_sort	Zenghui Qian
title	Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
title_short	Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
title_full	Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
title_fullStr	Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
title_full_unstemmed	Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients
title_sort	molecular characterization and clinical relevance of anxa1 in gliomas via 1,018 chinese cohort patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4582859f6da4444ca609fe4413c9d783
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Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients

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