Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of <italic toggle="yes">Paramyxoviridae</italic> and <italic toggle="yes">Pneumoviridae</italic>

Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of <italic toggle="yes">Paramyxoviridae</italic> and <italic toggle="yes">Pneumoviridae</italic>

ABSTRACT Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in A549 cells, a human lung adenocarcinoma cell line, we identif...

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Autores principales: Danielle E. Anderson, Kristin Pfeffermann, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, Yvonne Krebs, Kristmundur Sigmundsson, Sharon F. Jamison, Zhen Zhen Joanna Yeo, Linda J. Rennick, Lin-Fa Wang, Pierre J. Talbot, W. Paul Duprex, Mariano A. Garcia-Blanco, Veronika von Messling
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
ABCE1
Paramyxoviridae
Pneumoviridae
RNAi screen
host factor
respiratory syncytial virus
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/458b77fa67604a6a92aa29f115dcdb71
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