Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of <italic toggle="yes">Paramyxoviridae</italic> and <italic toggle="yes">Pneumoviridae</italic>

Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of <italic toggle="yes">Paramyxoviridae</italic> and <italic toggle="yes">Pneumoviridae</italic>

ABSTRACT Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in A549 cells, a human lung adenocarcinoma cell line, we identif...

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Auteurs principaux: Danielle E. Anderson, Kristin Pfeffermann, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, Yvonne Krebs, Kristmundur Sigmundsson, Sharon F. Jamison, Zhen Zhen Joanna Yeo, Linda J. Rennick, Lin-Fa Wang, Pierre J. Talbot, W. Paul Duprex, Mariano A. Garcia-Blanco, Veronika von Messling
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
Sujets:
ABCE1
Paramyxoviridae
Pneumoviridae
RNAi screen
host factor
respiratory syncytial virus
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/458b77fa67604a6a92aa29f115dcdb71
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