Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.

<h4>Introduction</h4>Testicular cancer is one of the most treatable cancers, with a 10-year survival of more than 95%. Many patients will be long-term survivors and this disease strikes men in an important phase of their lives, therefore the quality of life (QoL) among these patients is...

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Autores principales:	Aleksandar Jovanovski, Daniela Zugna, Daniela Di Cuonzo, Patrizia Lista, Libero Ciuffreda, Franco Merletti, Rosalba Rosato, Lorenzo Richiardi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/45938fffacbe47deaa4351761c2a2325
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spelling	oai:doaj.org-article:45938fffacbe47deaa4351761c2a23252021-12-02T20:17:15ZQuality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.1932-620310.1371/journal.pone.0258257https://doaj.org/article/45938fffacbe47deaa4351761c2a23252021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258257https://doaj.org/toc/1932-6203<h4>Introduction</h4>Testicular cancer is one of the most treatable cancers, with a 10-year survival of more than 95%. Many patients will be long-term survivors and this disease strikes men in an important phase of their lives, therefore the quality of life (QoL) among these patients is an area of particular interest. We aimed to study whether QoL in testicular cancer survivors depends on the time since cancer diagnosis.<h4>Methods</h4>Data were collected from the EPSAM (Esposizioni postnatali e salute maschile) study, a case-control study on patients with testicular cancer, diagnosed between 1997 and 2008 in the province of Turin, Northern Italy, and interviewed between 2008 and 2010 (response rate among cases 57%). Patients were contacted through their oncologist at the San Giovanni Batista Hospital in Turin or through their general practitioner (GP) in the rest of the Province of Turin. QoL was assessed cross-sectionally using the short form 12 (SF-12) questionnaire, a generic short-form health survey that produces two summary scores, PCS (physical component score) and MCS (mental component score), to evaluate physical and mental health, respectively.<h4>Results</h4>Out of 234 study patients, 125 cases were seminomas and 109 cases were nonseminomas. The mean age at diagnosis was 34.5 years. After adjusting for age, time since diagnosis was not associated with PCS and MCS scores. Among nonseminomas, the median PCS slightly increased (adjusted OR (odds ratio) for 5+ vs < 2 years since cancer diagnosis: 1.78 (1.17-2.73), p = 0.008) and MCS slightly decreased (adjusted OR per 1-year increase since cancer diagnosis: 0.92, 95% CI: 0.82-1.05, p = 0.23) with time. Similar findings of no association between time since diagnosis and PCS and MCS were found when the analyses were restricted to the subgroup of cancer patients contacted through their oncologist, whose response proportion was 82%.<h4>Conclusion</h4>In a study of testicular cancer patients interviewed cross-sectionally at 1 to more than 10 years since diagnosis, time since cancer diagnosis was not associated with QoL when we considered all germ-cell testicular cancer patients together. When stratified by histology type, we found certain evidence that nonseminoma cases report higher PCS over time since cancer diagnosis.Aleksandar JovanovskiDaniela ZugnaDaniela Di CuonzoPatrizia ListaLibero CiuffredaFranco MerlettiRosalba RosatoLorenzo RichiardiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258257 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aleksandar Jovanovski Daniela Zugna Daniela Di Cuonzo Patrizia Lista Libero Ciuffreda Franco Merletti Rosalba Rosato Lorenzo Richiardi Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
description	<h4>Introduction</h4>Testicular cancer is one of the most treatable cancers, with a 10-year survival of more than 95%. Many patients will be long-term survivors and this disease strikes men in an important phase of their lives, therefore the quality of life (QoL) among these patients is an area of particular interest. We aimed to study whether QoL in testicular cancer survivors depends on the time since cancer diagnosis.<h4>Methods</h4>Data were collected from the EPSAM (Esposizioni postnatali e salute maschile) study, a case-control study on patients with testicular cancer, diagnosed between 1997 and 2008 in the province of Turin, Northern Italy, and interviewed between 2008 and 2010 (response rate among cases 57%). Patients were contacted through their oncologist at the San Giovanni Batista Hospital in Turin or through their general practitioner (GP) in the rest of the Province of Turin. QoL was assessed cross-sectionally using the short form 12 (SF-12) questionnaire, a generic short-form health survey that produces two summary scores, PCS (physical component score) and MCS (mental component score), to evaluate physical and mental health, respectively.<h4>Results</h4>Out of 234 study patients, 125 cases were seminomas and 109 cases were nonseminomas. The mean age at diagnosis was 34.5 years. After adjusting for age, time since diagnosis was not associated with PCS and MCS scores. Among nonseminomas, the median PCS slightly increased (adjusted OR (odds ratio) for 5+ vs < 2 years since cancer diagnosis: 1.78 (1.17-2.73), p = 0.008) and MCS slightly decreased (adjusted OR per 1-year increase since cancer diagnosis: 0.92, 95% CI: 0.82-1.05, p = 0.23) with time. Similar findings of no association between time since diagnosis and PCS and MCS were found when the analyses were restricted to the subgroup of cancer patients contacted through their oncologist, whose response proportion was 82%.<h4>Conclusion</h4>In a study of testicular cancer patients interviewed cross-sectionally at 1 to more than 10 years since diagnosis, time since cancer diagnosis was not associated with QoL when we considered all germ-cell testicular cancer patients together. When stratified by histology type, we found certain evidence that nonseminoma cases report higher PCS over time since cancer diagnosis.
format	article
author	Aleksandar Jovanovski Daniela Zugna Daniela Di Cuonzo Patrizia Lista Libero Ciuffreda Franco Merletti Rosalba Rosato Lorenzo Richiardi
author_facet	Aleksandar Jovanovski Daniela Zugna Daniela Di Cuonzo Patrizia Lista Libero Ciuffreda Franco Merletti Rosalba Rosato Lorenzo Richiardi
author_sort	Aleksandar Jovanovski
title	Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
title_short	Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
title_full	Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
title_fullStr	Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
title_full_unstemmed	Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.
title_sort	quality of life among germ-cell testicular cancer survivors: the effect of time since cancer diagnosis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/45938fffacbe47deaa4351761c2a2325
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Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis.

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