Zone-specific damage of the olfactory epithelium under protein restriction

Abstract Oxidative stress causes tissue damage, affecting age-related pathologies. Protein restriction (PR) provides a powerful intervention strategy for reducing oxidative stress, which may have a positive effect on individual organs. However, it is unknown whether PR intervention influences the ol...

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Autores principales:	Ayinuer Tuerdi, Shu Kikuta, Makoto Kinoshita, Teru Kamogashira, Kenji Kondo, Tatsuya Yamasoba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4594e94f2c4b4f92aa28b4fefa554e34
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spelling	oai:doaj.org-article:4594e94f2c4b4f92aa28b4fefa554e342021-12-02T12:42:18ZZone-specific damage of the olfactory epithelium under protein restriction10.1038/s41598-020-79249-32045-2322https://doaj.org/article/4594e94f2c4b4f92aa28b4fefa554e342020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79249-3https://doaj.org/toc/2045-2322Abstract Oxidative stress causes tissue damage, affecting age-related pathologies. Protein restriction (PR) provides a powerful intervention strategy for reducing oxidative stress, which may have a positive effect on individual organs. However, it is unknown whether PR intervention influences the olfactory system. Here, we investigated how 10 months of PR could affect the cell dynamics of the olfactory epithelium (OE) in mice. We found that PR reduced age-related loss of outer hair cells in the cochlea, providing preventive effects against age-related hearing loss. In contrast, PR resulted in reduced mature olfactory sensory neurons (OSNs), increased proliferative basal cells, and increased apoptotic OSNs in zone 1 (the only area containing neurons expressing NQO1 [quinone dehydrogenase 1]) of the OE in comparison with animals given a control diet. Substantial oxidative stress occurred in NQO1-positive cells and induced apoptotic OSNs in zone 1. These results indicate that in contrast to the positive effect on the auditory system, PR induces oxidative stress and structurally and functionally negative effects on OSNs in zone 1, which is probably involved in the bioactivation of NQO1.Ayinuer TuerdiShu KikutaMakoto KinoshitaTeru KamogashiraKenji KondoTatsuya YamasobaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayinuer Tuerdi Shu Kikuta Makoto Kinoshita Teru Kamogashira Kenji Kondo Tatsuya Yamasoba Zone-specific damage of the olfactory epithelium under protein restriction
description	Abstract Oxidative stress causes tissue damage, affecting age-related pathologies. Protein restriction (PR) provides a powerful intervention strategy for reducing oxidative stress, which may have a positive effect on individual organs. However, it is unknown whether PR intervention influences the olfactory system. Here, we investigated how 10 months of PR could affect the cell dynamics of the olfactory epithelium (OE) in mice. We found that PR reduced age-related loss of outer hair cells in the cochlea, providing preventive effects against age-related hearing loss. In contrast, PR resulted in reduced mature olfactory sensory neurons (OSNs), increased proliferative basal cells, and increased apoptotic OSNs in zone 1 (the only area containing neurons expressing NQO1 [quinone dehydrogenase 1]) of the OE in comparison with animals given a control diet. Substantial oxidative stress occurred in NQO1-positive cells and induced apoptotic OSNs in zone 1. These results indicate that in contrast to the positive effect on the auditory system, PR induces oxidative stress and structurally and functionally negative effects on OSNs in zone 1, which is probably involved in the bioactivation of NQO1.
format	article
author	Ayinuer Tuerdi Shu Kikuta Makoto Kinoshita Teru Kamogashira Kenji Kondo Tatsuya Yamasoba
author_facet	Ayinuer Tuerdi Shu Kikuta Makoto Kinoshita Teru Kamogashira Kenji Kondo Tatsuya Yamasoba
author_sort	Ayinuer Tuerdi
title	Zone-specific damage of the olfactory epithelium under protein restriction
title_short	Zone-specific damage of the olfactory epithelium under protein restriction
title_full	Zone-specific damage of the olfactory epithelium under protein restriction
title_fullStr	Zone-specific damage of the olfactory epithelium under protein restriction
title_full_unstemmed	Zone-specific damage of the olfactory epithelium under protein restriction
title_sort	zone-specific damage of the olfactory epithelium under protein restriction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4594e94f2c4b4f92aa28b4fefa554e34
work_keys_str_mv	AT ayinuertuerdi zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction AT shukikuta zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction AT makotokinoshita zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction AT terukamogashira zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction AT kenjikondo zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction AT tatsuyayamasoba zonespecificdamageoftheolfactoryepitheliumunderproteinrestriction
_version_	1718393682032328704

Zone-specific damage of the olfactory epithelium under protein restriction

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