Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice...

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Autores principales:	Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/459b2972ed404c94bc46191739350a3c
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spelling	oai:doaj.org-article:459b2972ed404c94bc46191739350a3c2021-12-02T15:15:59ZRapid and direct control of target protein levels with VHL-recruiting dTAG molecules10.1038/s41467-020-18377-w2041-1723https://doaj.org/article/459b2972ed404c94bc46191739350a3c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18377-whttps://doaj.org/toc/2041-1723The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice.Behnam NabetFleur M. FergusonBo Kyung A. SeongMiljan KuljaninAlan L. LeggettMikaela L. MohardtAmanda RobichaudAmy S. ConwayDennis L. BuckleyJoseph D. ManciasJames E. BradnerKimberly StegmaierNathanael S. GrayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Behnam Nabet Fleur M. Ferguson Bo Kyung A. Seong Miljan Kuljanin Alan L. Leggett Mikaela L. Mohardt Amanda Robichaud Amy S. Conway Dennis L. Buckley Joseph D. Mancias James E. Bradner Kimberly Stegmaier Nathanael S. Gray Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
description	The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previously recalcitrant target proteins in cells and mice.
format	article
author	Behnam Nabet Fleur M. Ferguson Bo Kyung A. Seong Miljan Kuljanin Alan L. Leggett Mikaela L. Mohardt Amanda Robichaud Amy S. Conway Dennis L. Buckley Joseph D. Mancias James E. Bradner Kimberly Stegmaier Nathanael S. Gray
author_facet	Behnam Nabet Fleur M. Ferguson Bo Kyung A. Seong Miljan Kuljanin Alan L. Leggett Mikaela L. Mohardt Amanda Robichaud Amy S. Conway Dennis L. Buckley Joseph D. Mancias James E. Bradner Kimberly Stegmaier Nathanael S. Gray
author_sort	Behnam Nabet
title	Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
title_short	Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
title_full	Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
title_fullStr	Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
title_full_unstemmed	Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
title_sort	rapid and direct control of target protein levels with vhl-recruiting dtag molecules
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/459b2972ed404c94bc46191739350a3c
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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

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